(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Gene Therapy with Dominant-negative Stat3 Suppresses Growth of the Murine Melanoma B16 Tumor in Vivo1

Guilian Niu; Richard Heller; Robyn Catlett-Falcone; Domenico Coppola; Mark Jaroszeski; William Dalton; Richard Jove; Hua Yu

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Fusion of the EWS-related Gene TAF2N to TEC in Extraskeletal Myxoid Chondrosarcoma 1

Helene Sjögren; Jeanne Meis-Kindblom; Lars-Gunnar Kindblom; Pierre Åman; Göran Stenman

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Germ-line msh6 Mutations in Colorectal Cancer Families 1

Richard D. Kolodner; Jessica D. Tytell; James L. Schmeits; Michael F. Kane; Ruchira Das Gupta; John Weger; Siobhan Wahlberg; Edward A. Fox; David Peel; Argyrios Ziogas; Judy E. Garber; Sapna Syngal; Hoda Anton-Culver; Frederick P. Li

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MDM2 and MDMX Inhibit the Transcriptional Activity of Ectopically Expressed SMAD Proteins 1

Cain H. Yam; Wai Yi Siu; Talha Arooz; Clarissa H. S. Chiu; Anita Lau; Xiao Qi Wang; Randy Y. C. Poon

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A Novel Human Xenograft Model of Inflammatory Breast Cancer

Mary L. Alpaugh; James S. Tomlinson; Zhi-Ming Shao; Sanford H. Barsky

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Inhibition of Homologue of Slimb (HOS) Function Sensitizes Human Melanoma Cells for Apoptosis 1

Viatcheslav A. Soldatenkov; Anatoly Dritschilo; Ze’ev Ronai; Serge Y. Fuchs

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Compensatory Lung Growth after Partial Pneumonectomy Enhances Lung Tumorigenesis Induced by 3-Methylcholanthrene 1

Lynn M. Brown; Alvin M. Malkinson; D. Eugene Rannels; Stephen R. Rannels

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Comparative Studies of a Retrovirus versus a Poxvirus Vector in Whole Tumor-Cell Vaccines

James W. Hodge; Jeffrey Schlom

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p57^KIP2 Expression and Loss of Heterozygosity during Immortal Conversion of Cultured Human Mammary Epithelial Cells 1

Tarlochan Nijjar; Don Wigington; James C. Garbe; Andreas Waha; Martha R. Stampfer; Paul Yaswen

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Classification of Small Cell Lung Cancer and Pulmonary Carcinoid by Gene Expression Profiles 1

Ramaswamy Anbazhagan; Tarik Tihan; Daniel M. Bornman; James C. Johnston; Joel H. Saltz; Anthony Weigering; Steven Piantadosi; Edward Gabrielson

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Arginine Vasopressin Promoter Regulation Is Mediated by a Neuron-restrictive Silencer Element in Small Cell Lung Cancer 1

Judy M. Coulson; Carolyn E. Fiskerstrand; Penella J. Woll; John P. Quinn

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Angiogenic Activity of Human Soluble Intercellular Adhesion Molecule-1

Yong Song Gho; Hynda K. Kleinman; Gabriel Sosne

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Biochemistry

Role of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Cascade in Gonadotropin-releasing Hormone-induced Growth Inhibition of a Human Ovarian Cancer Cell Line

Akiko Kimura; Masahide Ohmichi; Hirohisa Kurachi; Hiromasa Ikegami; Jun Hayakawa; Keiichi Tasaka; Yuki Kanda; Yukihiro Nishio; Hiroaki Jikihara; Nariaki Matsuura; Yuji Murata

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Carcinogenesis

Polyethylene-glycol Suppresses Colon Cancer and Causes Dose-dependent Regression of Azoxymethane-induced Aberrant Crypt Foci in Rats 1

Géraldine Parnaud; Sylviane Taché; Ginette Peiffer; Denis E. Corpet

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Pancolonic Chromosomal Instability Precedes Dysplasia and Cancer in Ulcerative Colitis 1

Peter S. Rabinovitch; Shawna Dziadon; Teresa A. Brentnall; Mary J. Emond; David A. Crispin; Rodger C. Haggitt; Mary P. Bronner

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N-Oxidative Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in Humans Excretion of the N^2-Glucuronide Conjugate of 2-Hydroxyamino-MeIQx in Urine 1

W. G. Stillwell; Robert J. Turesky; Rashmi Sinha; Steven R. Tannenbaum

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Clinical Investigations

Induction of Immunity to Prostate Cancer Antigens: Results of a Clinical Trial of Vaccination with Irradiated Autologous Prostate Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-stimulating Factor Using ex Vivo Gene Transfer 1

Jonathan W. Simons; Bahar Mikhak; Ju-Fay Chang; Angelo M. DeMarzo; Michael A. Carducci; Michael Lim; Christine E. Weber; Angelo A. Baccala; Marti A. Goemann; Shirley M. Clift; Dale G. Ando; Hyam I. Levitsky; Lawrence K. Cohen; Martin G. Sanda; Richard C. Mulligan; Alan W. Partin; H. Ballentine Carter; Steven Piantadosi; Fray F. Marshall; William G. Nelson

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Sensitive Detection of K-ras Mutations Augments Diagnosis of Colorectal Cancer Metastases in the Liver

Carl C. Schimanski; Ulrich Linnemann; Martin R. Berger

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Endocrinology

Effects of the Antiestrogen EM-800 (SCH 57050) and Cyclophosphamide Alone and in Combination on Growth of Human ZR-75-1 Breast Cancer Xenografts in Nude Mice

Matthieu Gutman; Steeve Couillard; Fernand Labrie; Bernard Candas; Claude Labrie

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Epidemiology and Prevention

Risk Factors for Ki-ras Protooncogene Mutation in Sporadic Colorectal Adenomas 1

María Elena Martínez; Terese Maltzman; James R. Marshall; Janine Einspahr; Mary E. Reid; Richard Sampliner; Dennis J. Ahnen; Stanley R. Hamilton; David S. Alberts

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Experimental Therapeutics

Imaging Adenoviral-mediated Herpes Virus Thymidine Kinase Gene Transfer and Expression In Vivo1

Juri G. Tjuvajev; Shu Hsia Chen; Arjun Joshi; Revathi Joshi; Zong Sheng Guo; Julius Balatoni; Douglas Ballon; Jason Koutcher; Ronald Finn; Savio L. Woo; Ronald G. Blasberg

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Reversal of Radiation Resistance in LNCaP Cells by Targeting Apoptosis through Ceramide Synthase 1

Mark Garzotto; Adriana Haimovitz-Friedman; Wen-Chieh Liao; Margaret White-Jones; Robert Huryk; Warren D. W. Heston; Carlos Cardon-Cardo; Richard Kolesnick; Zvi Fuks

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Eradication of Primary Murine Fibrosarcomas and Induction of Systemic Immunity by Adenovirus-mediated Interferon β Gene Therapy 1

Weixin Lu; Isaiah J. Fidler; Zhongyun Dong

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Antivascular Endothelial Growth Factor Receptor (Fetal Liver Kinase 1) Monoclonal Antibody Inhibits Tumor Angiogenesis and Growth of Several Mouse and Human Tumors

Marie Prewett; James Huber; Yiwen Li; Angel Santiago; William O’Connor; Karen King; Jay Overholser; Andrea Hooper; Bronislaw Pytowski; Larry Witte; Peter Bohlen; Daniel J. Hicklin

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The Ribonucleoside Diphosphate Reductase Inhibitor (E)-2′-Deoxy-(fluoromethylene)cytidine as a Cytotoxic Radiosensitizer in Vitro1

Philippe A. Coucke; Laurent A. Decosterd; Ye-Xiong Li; Eliane Cottin; Xiaoguang Chen; Lin-Quan Sun; Sabine Stern; Nicolas Paschoud; Juliana Denekamp

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Shock Wave Permeabilization with Ribosome Inactivating Proteins: A New Approach to Tumor Therapy 1

Michael Delius; Gerhard Adams

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Enzyme Prodrug Gene Therapy: Synergistic Use of the Herpes Simplex Virus-Cellular Thymidine Kinase/Ganciclovir System and Thymidylate Synthase Inhibitors for the Treatment of Colon Cancer

Oliver Wildner; R. Michael Blaese; Fabio Candotti

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Radiosensitization of Human Tumor Cell Lines Induced by the Adenovirus-mediated Expression of an Anti-Ras Single-Chain Antibody Fragment 1

Jeffery S. Russell; Frederick F. Lang; Thierry Huet; Michel Janicot; Sunil Chada; Deborah R. Wilson; Philip J. Tofilon

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Immunology

Infiltration of Tumors by Systemically Transferred Tumor-Reactive T Lymphocytes Is Required for Antitumor Efficacy 1

Shigehiko Mukai; Jørgen Kjærgaard; Suyu Shu; Gregory E. Plautz

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Successful Immunotherapy of an Intraocular Tumor in Mice 1

Luc R. H. M. Schurmans; Annemieke Th. den Boer; Linda Diehl; Ellen I. H. van der Voort; W. Martin Kast; Cornelis J. M. Melief; René E. M. Toes; Martine J. Jager

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A Chimeric Cell Adhesion Molecule Mediates Homing of Lymphocytes to Vascularized Tumors 1

Guido Wiedle; Caroline Johnson-Léger; Beat A. Imhof

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Regression of Established B16F10 Melanoma with a Recombinant Listeria monocytogenes Vaccine 1

Zhen-Kun Pan; Larry M. Weiskirch; Yvonne Paterson

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Molecular Biology and Genetics

Abnormal Fhit Expression in Malignant and Premalignant Lesions of the Cervix

Michael J. Birrer; Denver Hendricks; John Farley; Michael J. Sundborg; Tomas Bonome; Michael J. Walts; Joseph Geradts

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Structure-Function Studies of the BTB/POZ Transcriptional Repression Domain from the Promyelocytic Leukemia Zinc Finger Oncoprotein 1

Xinmin Li; Hongzhuang Peng; David C. Schultz; Jesus M. Lopez-Guisa; Frank J. Rauscher, III; Ronen Marmorstein

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The Relationship of DNA Ploidy to Chromosomal Instability in Primary Human Colorectal Cancers 1

Mutsuko Miyazaki; Tomoko Furuya; Akiko Shiraki; Toshihiko Sato; Atsunori Oga; Kohsuke Sasaki

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Regulation by p38 Mitogen-activated Protein Kinase of Adenylate- and Uridylate-Rich Element-mediated Urokinase-Type Plasminogen Activator (uPA) Messenger RNA Stability and uPA-dependent in Vitro Cell Invasion

Lilian Montero; Yoshikuni Nagamine

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Ataxia Telangiectasia Mutated Deficiency Affects Astrocyte Growth but not Radiosensitivity 1

Eric C. Gosink; Miriam J. Chong; Peter J. McKinnon

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Tumor Biology

Characterization of Glycosylphosphatidylinositol-linked Molecule CD55/Decay-accelerating Factor as the Receptor for Antibody SC-1-induced Apoptosis 1

Frank Hensel; Ralph Hermann; Christian Schubert; Nico Abé; Karsten Schmidt; Axel Franke; Andrej Shevchenko; Matthias Mann; Hans Konrad Müller-Hermelink; H. Peter Vollmers

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Urokinase Receptor Interacts with α_vβ₅ Vitronectin Receptor, Promoting Urokinase-dependent Cell Migration in Breast Cancer 1

Maria V. Carriero; Silvana Del Vecchio; Monica Capozzoli; Paola Franco; Laura Fontana; Antonella Zannetti; Gerardo Botti; Giuseppe D’Aiuto; Marco Salvatore; M. Patrizia Stoppelli

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Ribozyme-mediated Down-Regulation of ErbB-4 in Estrogen Receptor-positive Breast Cancer Cells Inhibits Proliferation Both in Vitro and in Vivo1

Careen K. Tang; Xiao-Zheng Wu Concepcion; Melissa Milan; Xiaoqi Gong; Elizabeth Montgomery; Marc E. Lippman

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Apoptosis Induction of Human Lung Cancer Cell Line in Multicellular Heterospheroids with Humanized Antiganglioside GM2 Monoclonal Antibody

Kazuyasu Nakamura; Masaki Hanibuchi; Seiji Yano; Yuko Tanaka; Ikuko Fujino; Miho Inoue; Toshiaki Takezawa; Kenya Shitara; Saburo Sone; Nobuo Hanai

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Biological Activities and Signaling Pathways of the Granulin/Epithelin Precursor 1

Tommaso Zanocco-Marani; Andrew Bateman; Gaetano Romano; Barbara Valentinis; Zhi-Heng He; Renato Baserga

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Microinjection of Anti-p21 Antibodies Induces Senescent Hs68 Human Fibroblasts to Synthesize DNA but not To Divide 1

Yuliang Ma; Sally A. Prigent; Teresa L. Born; Craig R. Monell; James R. Feramisco; Bonnie L. Bertolaet

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A Mammalian Severin Replaces Gelsolin in Transformed Epithelial Cells 1

Paula A. Folger; William J. Berg; Zoraida DeJesus; Yuman Fong; Joel D. Pardee

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Fas Ligand Is Expressed on Human Squamous Cell Carcinomas of the Head and Neck, and It Promotes Apoptosis of T Lymphocytes 1

Brian R. Gastman; Yoshinari Atarashi; Torsten E. Reichert; Takao Saito; Levent Balkir; Hannah Rabinowich; Theresa L. Whiteside

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Response of Human Tumor Cells of Varying Radiosensitivity and Radiocurability to Fractionated Irradiation 1

William K. Dahlberg; Edouard I. Azzam; Yongjia Yu; John B. Little

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Distinctive Expression and Functions of the Type 4 Endothelial Differentiation Gene-encoded G Protein-coupled Receptor for Lysophosphatidic Acid in Ovarian Cancer 1

Edward J. Goetzl; Hana Dolezalova; Yvonne Kong; Yu-Long Hu; Robert B. Jaffe; Kimberly R. Kalli; Cheryl A. Conover

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Signaling Pathways and Structural Domains Required for Phosphorylation of EMS1/Cortactin 1

Douglas H. Campbell; Robert L. Sutherland; Roger J. Daly

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Immunohistochemical Localization of Caspase-3 Correlates with Clinical Outcome in B-Cell Diffuse Large-Cell Lymphoma 1

Stephen Donoghue; Hussein S. Baden; Ian Lauder; Stanislaw Sobolewski; James Howard Pringle

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Gangliosides Influence Angiogenesis in an Experimental Mouse Brain Tumor 1

Mark G. Manfredi; Sangmook Lim; Kevin P. Claffey; Thomas N. Seyfried

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Errata

R. W. Kozak et. al., 49: 2639–2644, 1999

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Correction

Y-Y. E. Chuang et al., 59: 3073–3076, 1999

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Advances in Brief

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