(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Childhood Hepatoblastomas Frequently Carry a Mutated Degradation Targeting Box of the β-Catenin Gene 1

Arend Koch; Dorota Denkhaus; Steffen Albrecht; Ivo Leuschner; Dietrich von Schweinitz; Torsten Pietsch

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Perivascular Cells Harboring Multiple Endocrine Neoplasia Type 1 Alterations Are Neoplastic Cells in Angiofibromas

Alexander O. Vortmeyer; Roland Böni; Svetlana D. Pack; Thomas N. Darling; Zhengping Zhuang

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Activation of Mitogen-Activated Protein Kinase Associated with Prostate Cancer Progression 1

Daniel Gioeli; James W. Mandell; Gina R. Petroni; Henry F. Frierson, Jr.; Michael J. Weber

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The Multilayered Organization of Engineered Human Skin Does Not Influence the Formation of Sunlight-induced Cyclobutane Pyrimidine Dimers in Cellular DNA 1

Jean-Philippe Therrien; Mahmoud Rouabhia; Elliot A. Drobetsky; Régen Drouin

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Human MLH1 Deficiency Predisposes to Hematological Maligancy and Neurofibromatosis Type 1 1

Marie D. Ricciardone; Tayfun Özçelik; Birsen Cevher; Hilal Özdağ; Murat Tuncer; Aytemiz Gürgey; Özden Uzunalimoğlu; Hülya Çetinkaya; Attila Tanyeli; Eren Erken; Mehmet Öztürk

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Neurofibromatosis and Early Onset of Cancers in hMLH1-deficient children 1

Qing Wang; Christine Lasset; Françoise Desseigne; Didier Frappaz; Christophe Bergeron; Claudine Navarro; Eric Ruano; Alain Puisieux

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Asbestos and DNA Double Strand Breaks 1

Ryuichi Okayasu; Sentaro Takahashi; Shigeru Yamada; Tom K. Hei; Robert L. Ullrich

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A Superagonist Variant of Peptide MART1/Melan A_27–35 Elicits Anti-Melanoma CD8⁺ T Cells with Enhanced Functional Characteristics: Implication for More Effective Immunotherapy 1

Licia Rivoltini; Paola Squarcina; Douglas J. Loftus; Chiara Castelli; Paolo Tarsini; Arabella Mazzocchi; Francesca Rini; Vincenzo Viggiano; Filiberto Belli; Giorgio Parmiani

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Somatic Mutations in the Kinase Domain of the Met/Hepatocyte Growth Factor Receptor Gene in Childhood Hepatocellular Carcinomas 1

Won Sang Park; Seung Myung Dong; Su Young Kim; Eun Young Na; Min Sun Shin; Jae Ho Pi; Bum Jun Kim; Jeong Hoon Bae; Young Ki Hong; Kyo Sun Lee; Sug Hyung Lee; Nam Jin Yoo; Ja June Jang; Svetlana Pack; Zhengping Zhuang; Laura Schmidt; Berton Zbar; Jung Young Lee

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Deletion of Chromosome 1 Predicts Prognosis in Pancreatic Endocrine Tumors 1

Sam A. Ebrahimi; Eric H. Wang; Alan Wu; Rhona R. Schreck; Edward Passaro, Jr.; Mark P. Sawicki

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Glioblastoma Cell-specific Expression of Fibroblast Growth Factor Receptor-1β Requires an Intronic Repressor of RNA Splicing 1

Wei Jin; Weiqi Bi; Eileen S-C. Huang; Gilbert J. Cote

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Mutational Inactivation of Transforming Growth Factor β Receptor Type II in Microsatellite Stable Colon Cancers 1

William M. Grady; Lois L. Myeroff; Sandra E. Swinler; Ashwani Rajput; Sam Thiagalingam; James D. Lutterbaugh; Aaron Neumann; Michael G. Brattain; Jay Chang; Seong-Jin Kim; Ken W. Kinzler; Bert Vogelstein; James K. V. Willson; Sanford Markowitz

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Loss of Adenoviral Receptor Expression in Human Bladder Cancer Cells: A Potential Impact on the Efficacy of Gene Therapy 1

Yingming Li; Rey-Chen Pong; Jeffrey M. Bergelson; M. Craig Hall; Arthur I. Sagalowsky; Ching-Ping Tseng; Zhi Wang; Jer-Tsong Hsieh

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Photodynamic Therapy Sensitivity Is Not Altered in Human Tumor Cells after Abrogation of p53 Function 1

Anita M. R. Fisher; Angela Ferrario; Natalie Rucker; Sha Zhang; Charles J. Gomer

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A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity 1

Nanjoo Suh; Yongping Wang; Tadashi Honda; Gordon W. Gribble; Ethan Dmitrovsky; William F. Hickey; Robert A. Maue; Andrew E. Place; Donna M. Porter; Michael J. Spinella; Charlotte R. Williams; Gengfei Wu; Andrew J. Dannenberg; Kathleen C. Flanders; John J. Letterio; David J. Mangelsdorf; Carl F. Nathan; Lananh Nguyen; Weston W. Porter; Renee F. Ren; Anita B. Roberts; Nanette S. Roche; Kotha Subbaramaiah; Michael B. Sporn

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Transcription Factor Y-Box Binding Protein 1 Binds Preferentially to Cisplatin-modified DNA and Interacts with Proliferating Cell Nuclear Antigen 1

Tomoko Ise; Gunji Nagatani; Toshihiro Imamura; Ken Kato; Hiroshi Takano; Minoru Nomoto; Hiroto Izumi; Haruki Ohmori; Tatsuro Okamoto; Takefumi Ohga; Takeshi Uchiumi; Michihiko Kuwano; Kimitoshi Kohno

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Biochemistry

Increased Binding Affinity and Valence of Recombinant Antibody Fragments Lead to Improved Targeting of Tumoral Angiogenesis 1

Francesca Viti; Lorenzo Tarli; Leonardo Giovannoni; Luciano Zardi; Dario Neri

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Carcinogenesis

Genotype-Phenotype Correlation in Murine Apc Mutation: Differences in Enterocyte Migration and Response to Sulindac 1

Najjia N. Mahmoud; Robyn T. Bilinski; Matthew R. Churchill; Winfried Edelmann; Raju Kucherlapati; Monica M. Bertagnolli

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Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer

Hiroshi Ikawa; Hideki Kamitani; Benjamin F. Calvo; Julie F. Foley; Thomas E. Eling

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Interleukin 8: An Autocrine Growth Factor for Malignant Mesothelioma

Gabriella Galffy; Kamal A. Mohammed; Patrick A. Dowling; Najmunnisa Nasreen; Melissa J. Ward; Veena B. Antony

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Endocrinology

The Pure Antiestrogen ICI 182,780 Inhibits Progestin-induced Transcription 1

Zafar Nawaz; George M. Stancel; Salman M. Hyder

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Steroid Sulfatase Expression Is an Independent Predictor of Recurrence in Human Breast Cancer 1

Toshiaki Utsumi; Noriko Yoshimura; Shinji Takeuchi; Jiro Ando; Morito Maruta; Kotaro Maeda; Nobuhiro Harada

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Experimental Therapeutics

Signaling Pathway Activated during Apoptosis of the Prostate Cancer Cell Line LNCaP: Overexpression of Caspase-7 as a New Gene Therapy Strategy for Prostate Cancer 1

Marco Marcelli; Glenn R. Cunningham; Margaret Walkup; Zening He; Lydia Sturgis; Carolina Kagan; Roberta Mannucci; Ildo Nicoletti; BaBie Teng; Larry Denner

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Activation of c-Jun NH₂-terminal Kinase and Subsequent CPP32/Yama during Topoisomerase Inhibitor β-Lapachone-induced Apoptosis through an Oxidation-dependent Pathway 1

Shine-Gwo Shiah; Shuang-En Chuang; Yat-Pang Chau; Shing-Chuan Shen; Min-Liang Kuo

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Histone Deacetylase Inhibitors as Potential Anti-Skin Cancer Agents 1

Nicholas Saunders; Anthony Dicker; Claudia Popa; Susan Jones; Alison Dahler

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The Use of Zn-Desferrioxamine for Radioprotection in Mice, Tissue Culture, and Isolated DNA 1

Yuval Samuni; Deborah Coffin; Anne Marie DeLuca; William G. DeGraff; David J. Venson; Indu Ambudkar; Mordechai Chevion; James B. Mitchell

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Therapy of Colon Cancer with Oncolytic Adenovirus Is Enhanced by the Addition of Herpes Simplex Virus-thymidine kinase

Oliver Wildner; R. Michael Blaese; John C. Morris

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Immunology

Immune Events Associated with the Cure of Established Tumors and Spontaneous Metastases by Local and Systemic Interleukin 12 1

Federica Cavallo; Emma Di Carlo; Monia Butera; Roberta Verrua; Mario P. Colombo; Piero Musiani; Guido Forni

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The Pharmacokinetic Characteristics of Glycolated Humanized Anti-Tac Fabs Are Determined by Their Isoelectric Points

Hisataka Kobayashi; Nhat Le; In-sook Kim; Meyoung-Kon Kim; Jae-Eun Pie; Debra Drumm; David S. Paik; Thomas A. Waldmann; Chang H. Paik; Jorge A. Carrasquillo

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Identification of HLA-A3-restricted Cytotoxic T Lymphocyte Epitopes from Carcinoembryonic Antigen and HER-2/neu by Primary in Vitro Immunization with Peptide-pulsed Dendritic Cells 1

Ichiro Kawashima; Van Tsai; Scott Southwood; Kazutoh Takesako; Alessandro Sette; Esteban Celis

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Molecular Biology and Genetics

Extensive Intra- and Interindividual Heterogeneity of ^p15INK4B Methylation in Acute Myeloid Leukemia 1

Anni Aggerholm; Per Guldberg; Marianne Hokland; Peter Hokland

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Tumor Suppressor PTEN Inhibition of Cell Invasion, Migration, and Growth: Differential Involvement of Focal Adhesion Kinase and p130^Cas

Masahito Tamura; Jianguo Gu; Takahisa Takino; Kenneth M. Yamada

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Comparative Genomic Hybridization and Loss of Heterozygosity Analyses Identify a Common Region of Deletion at 15q11.1–15 in Human Malignant Mesothelioma 1

Binaifer R. Balsara; Daphne W. Bell; Gonosuke Sonoda; Assunta De Rienzo; Stanislas du Manoir; Suresh C. Jhanwar; Joseph R. Testa

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Screening for Germ-Line Rearrangements and Regulatory Mutations in BRCA1 Led to the Identification of Four New Deletions 1

Nadine Puget; Dominique Stoppa-Lyonnet; Olga M. Sinilnikova; Sabine Pagès; Henry T. Lynch; Gilbert M. Lenoir; Sylvie Mazoyer

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Causes and Consequences of Microsatellite Instability in Endometrial Carcinoma 1

Cheryl C. Gurin; Mark G. Federici; Lan Kang; Jeff Boyd

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Tumor Biology

Enhanced Production and Activation of Progelatinase A Mediated by Membrane-Type 1 Matrix Metalloproteinase in Human Papillary Thyroid Carcinomas 1

Hiroyuki Nakamura; Hirohisa Ueno; Kaname Yamashita; Taketoshi Shimada; Etsuhide Yamamoto; Masakuni Noguchi; Noboru Fujimoto; Hiroshi Sato; Motoharu Seiki; Yasunori Okada

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12-O-Tetradecanoylphorbol-13-acetate Induces Clonal Expansion of Potentially Malignant Keratinocytes in a Tissue Model of Early Neoplastic Progression 1

Jeffrey Karen; Youai Wang; Ashkan Javaherian; Michael Vaccariello; Norbert E. Fusenig; Jonathan A. Garlick

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Mannosylerythritol Lipid Is a Potent Inducer of Apoptosis and Differentiation of Mouse Melanoma Cells in Culture 1

Xiaoxian Zhao; Yoko Wakamatsu; Miki Shibahara; Nobuhiko Nomura; Christian Geltinger; Tadaatsu Nakahara; Takehide Murata; Kazunari K. Yokoyama

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Meeting Report

Angiogenesis and Cancer: AACR Special Conferene in Cancer Research

Michael Klagsbrun

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Ninth Annual Pezcoller Symposium: The Biology of Tumors

Enrico Mihich; Carlo M. Croce

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Innovative Approaches to the Prevention, Diagnosis, and Therapy of Cancer: Fourth Joint Conference of the American Association for Cancer Research (AACR) and the Japan Cancer Association (JCA)

Kaoru Abe; Edward Bresnick

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Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

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