(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Public Issues

Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research 1^,2

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Perspectives in Cancer Research

Application of Complementary DNA Microarray Technology to Carcinogen Identification, Toxicology, and Drug Safety Evaluation

Cynthia A. Afshari; Emile F. Nuwaysir; J. Carl Barrett

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Advances in Brief

Response of Prostate Cancer to Anti-Her-2/neu Antibody in Androgen-dependent and -independent Human Xenograft Models 1

David B. Agus; Howard I. Scher; Brian Higgins; William D. Fox; Glenn Heller; Melissa Fazzari; Carlos Cordon-Cardo; David W. Golde

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Dominant-Negative Mutations of the Tumor Suppressor p53 Relating to Early Onset of Glioblastoma Multiforme 1

Masumi Marutani; Hidefumi Tonoki; Mitsuhiro Tada; Masato Takahashi; Haruhiko Kashiwazaki; Yasuhiro Hida; Jun-ich Hamada; Masahiro Asaka; Tetsuya Moriuchi

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Tumor Development under Angiogenic Signaling: A Dynamical Theory of Tumor Growth, Treatment Response, and Postvascular Dormancy 1

Philip Hahnfeldt; Dipak Panigrahy; Judah Folkman; Lynn Hlatky

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Addition of Peroxisome Proliferator-activated Receptor α to Guinea Pig Hepatocytes Confers Increased Responsiveness to Peroxisome Proliferators

Neil Macdonald; Peter R. Holden; Ruth A. Roberts

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Solid Tissues Removed from Atm Homozygous Deficient Mice Do Not Exhibit a Mutator Phenotype for Second-Step Autosomal Mutations 1

Mitchell S. Turker; Blythe M. Gage; Jennifer A. Rose; Olga N. Ponomareva; Jay A. Tischfield; Peter J. Stambrook; Carrolee Barlow; Anthony Wynshaw-Boris

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p53-Mutant Clones and Field Effects in Barrett’s Esophagus 1

Laura J. Prevo; Carissa A. Sanchez; Patricia C. Galipeau; Brian J. Reid

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Functional Activity of Ectopically Expressed Estrogen Receptor Is Not Sufficient for Estrogen-mediated Cyclin D1 Expression 1

Maricarmen D. Planas-Silva; Joana Liu Donaher; Robert A. Weinberg

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The Expression of a Truncated HMGI-C Gene Induces Gigantism Associated with Lipomatosis

Sabrina Battista; Vincenzo Fidanza; Monica Fedele; Andres J. P. Klein-Szanto; Eric Outwater; Han Brunner; Massimo Santoro; Carlo M. Croce; Alfredo Fusco

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Loss of Fhit Is Frequent in Stage I Non-Small Cell Lung Cancer and in the Lungs of Chronic Smokers 1

Jennifer E. Tseng; Bonnie L. Kemp; Fadlo R. Khuri; Jonathan M. Kurie; Jin Soo Lee; Xiao Zhou; Diane Liu; Waun Ki Hong; Li Mao

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Extracellular Signal-regulated Kinase Activation Is Required for Up-Regulation of Vascular Endothelial Growth Factor by Serum Starvation in Human Colon Carcinoma Cells 1

Young D. Jung; Kayo Nakano; Wenbiao Liu; Gary E. Gallick; Lee M. Ellis

Abstract

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Biochemistry

Decreased Sensitivity to 1-O-Octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 Cells Adapted for Serum-free Growth Correlates with Constitutive Association of Raf-1 with Cellular Membranes 1

Pranati Samadder; Gilbert Arthur

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Additivity of Dilantin and Vinblastine Inhibitory Effects on Microtubule Assembly 1

Sharon Lobert; Jeffrey W. Ingram; John J. Correia

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Carcinogenesis

High-Salt Diet Induces Gastric Epithelial Hyperplasia and Parietal Cell Loss, and Enhances Helicobacter pylori Colonization in C57BL/6 Mice 1

James G. Fox; Charles A. Dangler; Nancy S. Taylor; Amy King; Theodore J. Koh; Timothy C. Wang

Abstract

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Tamoxifen-DNA Adduct Formation in Rat Liver Determined by Immunoassay and ³²P-Postlabeling

Rao L. Divi; Martin R. Osborne; Alan Hewer; David H. Phillips; Miriam C. Poirier

Abstract

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Loss of Responsiveness to Transforming Growth Factor β Induces Malignant Transformation of Nontumorigenic Rat Prostate Epithelial Cells

Binwu Tang; Katherine de Castro; Helen E. Barnes; W. Tony Parks; LaMonica Stewart; Erwin P. Böttinger; David Danielpour; Lalage M. Wakefield

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Extracellular Matrix and Radiation G₁ Cell Cycle Arrest in Human Fibroblasts 1

Mira Dimitrijevic-Bussod; Viviana S. Balzaretti-Maggi; Donna M. Gadbois

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Endocrinology

Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p53 1

Ida Stenfeldt Mathiasen; Ulrikm Lademann; Marja Jäättelä

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Effect of Combined Treatment with the Pure Antiestrogen EM-800 and Radiotherapy on the Growth of Human ZR-75-1 Breast Cancer Xenografts in Nude Mice

Steeve Couillard; Matthieu Gutman; Fernand Labrie; Bernard Candas; Claude Labrie

Abstract

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Adrenal Androgens Stimulate the Proliferation of Breast Cancer Cells as Direct Activators of Estrogen Receptor α 1

Marcello Maggiolini; Olivier Donzé; Elisabeth Jeannin; Sebastiano Andò; Didier Picard

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Epidemiology and Prevention

Breast Cancer Risk Associated with Genotype Polymorphism of the Estrogen-metabolizing Genes CYP17, CYP1A1, and COMT: A Multigenic Study on Cancer Susceptibility

Chiun-Sheng Huang; Herng-Der Chern; King-Jen Chang; Chun-Wen Cheng; Su-Ming Hsu; Chen-Yang Shen

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Experimental Therapeutics

Antisense Cyclin D1 Induces Apoptosis and Tumor Shrinkage in Human Squamous Carcinomas 1

Edward R. Sauter; Mark Nesbit; Samuel Litwin; Andres J. P. Klein-Szanto; Susan Cheffetz; Meenhard Herlyn

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Hypoxia-mediated Apoptosis from Angiogenesis Inhibition Underlies Tumor Control by Recombinant Interleukin 12 1

Michael S. Gee; Cameron J. Koch; Sydney M. Evans; W. Timothy Jenkins; Charles H. Pletcher, Jr.; Jonni S. Moore; Holly K. Koblish; Jungeun Lee; Edith M. Lord; Giorgio Trinchieri; William M. F. Lee

Abstract

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Mouse Transporter Protein, a Membrane Protein That Regulates Cellular Multidrug Resistance, Is Localized to Lysosomes 1

Miguel A. Cabrita; Tom C. Hobman; Douglas L. Hogue; Karen M. King; Carol E. Cass

Abstract

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Potent Topoisomerase I Inhibition by Novel Silatecans Eliminates Glioma Proliferation in Vitro and in Vivo1

Ian F. Pollack; Melanie Erff; David Bom; Thomas G. Burke; J. Thompson Strode; Dennis P. Curran

Abstract

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Application of the Cre Recombinase/loxP System Further Enhances Antitumor Effects in Cell Type-specific Gene Therapy against Carcinoembryonic Antigen-producing Cancer 1

Takashi Kijima; Tadashi Osaki; Kazumi Nishino; Toru Kumagai; Toshiki Funakoshi; Hiroyuki Goto; Isao Tachibana; Yoshiro Tanio; Tadamitsu Kishimoto

Abstract

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Electromotive versus Passive Diffusion of Mitomycin C into Human Bladder Wall: Concentration-Depth Profiles Studies

Savino M. Di Stasi; Antonella Giannantoni; Renato Massoud; Susanna Dolci; Pierluigi Navarra; Giuseppe Vespasiani; Robert L. Stephen

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Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine 1

Jiazhi Sun; Michelle A. Blaskovich; David Knowles; Yimin Qian; Junko Ohkanda; Ratna D. Bailey; Andrew D. Hamilton; Saïd M. Sebti

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Transfection of 9-Hydroxyellipticine-resistant Chinese Hamster Fibroblasts with Human Topoisomerase IIα cDNA: Selective Restoration of the Sensitivity to DNA Religation Inhibitors 1

Tayeb Khélifa; Brigitte René; Sandrine Le Mée; Bernard Lambert; Jean-Marie Saucier; Judith Markovits; Hélène Jacquemin-Sablon; Alain Jacquemin-Sablon

Abstract

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Arabinosylguanine-induced Apoptosis of T-Lymphoblastic Cells: Incorporation into DNA Is a Necessary Step 1

Carlos O. Rodriguez, Jr.; Varsha Gandhi

Abstract

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The Polyamine Oxidase Inhibitor MDL-72,527 Selectively Induces Apoptosis of Transformed Hematopoietic Cells through Lysosomotropic Effects 1

Haiqing Dai; Debora L. Kramer; Chunying Yang; K. Gopal Murti; Carl W. Porter; John L. Cleveland

Abstract

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Immunology

Modified Vaccinia Virus Ankara for Delivery of Human Tyrosinase as Melanoma-associated Antigen: Induction of Tyrosinase- and Melanoma-specific Human Leukocyte Antigen A0201-restricted Cytotoxic T Cells in Vitro* and in Vivo1

Ingo Drexler; Edite Antunes; Marc Schmitz; Thomas Wölfel; Christoph Huber; Volker Erfle; Peter Rieber; Matthias Theobald; Gerd Sutter

Abstract

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Potent Activity of Soluble B7-IgG Fusion Proteins in Therapy of Established Tumors and as Vaccine Adjuvant

Knut Sturmhoefel; Kwang Lee; Gary S. Gray; Jenifer Thomas; Richard Zollner; Margot O’Toole; Holly Swiniarski; Andrew Dorner; Stanley F. Wolf

Abstract

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Molecular Biology and Genetics

Expression of OVCA1, a Candidate Tumor Suppressor, Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells 1

Wendy Bruening; Amanda H. Prowse; David C. Schultz; Marina Holgado-Madruga; Albert Wong; Andrew K. Godwin

Abstract

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Kaposi’s Sarcoma-associated Herpesvirus-encoded v-Cyclin Triggers Apoptosis in Cells with High Levels of Cyclin-dependent Kinase 6 1

Päivi M. Ojala; Marianne Tiainen; Petri Salven; Tanja Veikkola; Esmeralda Castaños-Vélez; Ronit Sarid; Peter Biberfeld; Tomi P. Mäkelä

Abstract

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Identification and Characterization of Genes Associated with Human Hepatocellular Carcinogenesis

Nobuo Kondoh; Toru Wakatsuki; Akihide Ryo; Akiyuki Hada; Tsukasa Aihara; Sankichi Horiuchi; Narihide Goseki; Osamu Matsubara; Kenji Takenaka; Mizue Shichita; Kenji Tanaka; Masahiro Shuda; Mikio Yamamoto

Abstract

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Genomic Structure, Chromosomal Mapping, and Promoter Region Analysis of Murine Uridine Phosphorylase Gene 1

Deliang Cao; Manjunath A. Nimmakayalu; Feiya Wang; Dekai Zhang; Robert E. Handschumacher; Patricia Bray-Ward; Giuseppe Pizzorno

Abstract

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Tumor Biology

Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium 1

Aria F. Olumi; Gary D. Grossfeld; Simon W. Hayward; Peter R. Carroll; Thea D. Tlsty; Gerald R. Cunha

Abstract

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In Vivo Prediction of Vascular Susceptibility to Vascular Endothelial Growth Factor Withdrawal: Magnetic Resonance Imaging of C6 Rat Glioma in Nude Mice 1

Rinat Abramovitch; Hagit Dafni; Eitzik Smouha; Laura E. Benjamin; Michal Neeman

Abstract

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Paradoxical Inhibition of c-myc-induced Carcinogenesis by Bcl-2 in Transgenic Mice 1

Alix de La Coste; Alexandre Mignon; Monique Fabre; Emmanuelle Gilbert; Arlette Porteu; Terry Van Dyke; Axel Kahn; Christine Perret

Abstract

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Overexpression of Fibroblast Growth Factor 1 in MCF-7 Breast Cancer Cells Facilitates Tumor Cell Dissemination but Does Not Support the Development of Macrometastases in the Lungs or Lymph Nodes 1

Lurong Zhang; Samir Kharbanda; Sandra W. McLeskey; Francis G. Kern

Abstract

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Evidence for Clonal Outgrowth of Androgen-independent Prostate Cancer Cells from Androgen-dependent Tumors through a Two-Step Process 1

Noah Craft; Chloe Chhor; Chris Tran; Arie Belldegrun; Jean DeKernion; Owen N. Witte; Jonathan Said; Robert E. Reiter; Charles L. Sawyers

Abstract

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Thymidine Phosphorylase Expression Is Associated with Both Increase of Intratumoral Microvessels and Decrease of Apoptosis in Human Colorectal Carcinomas 1

Takahiko Matsuura; Itaru Kuratate; Kazuki Teramachi; Mitsuhiko Osaki; Yasuhiko Fukuda; Hisao Ito

Abstract

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A Soluble Transforming Growth Factor β Type III Receptor Suppresses Tumorigenicity and Metastasis of Human Breast Cancer MDA-MB-231 Cells 1

Abhik Bandyopadhyay; Yong Zhu; Michael L. Cibull; LiWei Bao; Changguo Chen; LuZhe Sun

Abstract

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Induction of Apoptosis by Arachidonic Acid in Chronic Myeloid Leukemia Cells 1

Maria Teresa Rizzo; Ester Regazzi; Daniela Garau; Luke Akard; Michael Dugan; H. Scott Boswell; Vittorio Rizzoli; Carmelo Carlo-Stella

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Table of Contents

Public Issues

Perspectives in Cancer Research

Advances in Brief

Biochemistry

Carcinogenesis

Endocrinology

Epidemiology and Prevention

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

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