(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Perspectives in Cancer Research

On the Prevention and Therapy of Prostate Cancer by Androgen Administration

Richmond T. Prehn

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Advances in Brief

Mutational Analysis of the p63/p73L/p51/p40/CUSP/KET Gene in Human Cancer Cell Lines Using Intronic Primers

Koichi Hagiwara; Mary G. McMenamin; Ko Miura; Curtis C. Harris

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Alterations of the PPP1R3 Gene in Human Cancer 1

Takashi Kohno; Satoshi Takakura; Tatsuya Yamada; Aikou Okamoto; Tadao Tanaka; Jun Yokota

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Telomerase-negative Immortalized Human Cells Contain a Novel Type of Promyelocytic Leukemia (PML) Body 1

Thomas R. Yeager; Axel A. Neumann; Anna Englezou; Lily I. Huschtscha; Jane R. Noble; Roger R. Reddel

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Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS21

Biaoyang Lin; Camari Ferguson; James T. White; Shunyou Wang; Robert Vessella; Lawrence D. True; Leroy Hood; Peter S. Nelson

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Ultraviolet Radiation Induces p16^CDKN2A Expression in Human Skin 1

Sandra Pavey; Sinead Conroy; Terry Russell; Brian Gabrielli

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Expression of the Steroid Receptor RNA Activator in Human Breast Tumors 1

Etienne Leygue; Helmut Dotzlaw; Peter H. Watson; Leigh C. Murphy

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Metallothionein Is Overexpressed by Hamster Fibroblasts Selected for Growth in 15 pm Folinic Acid and Provides a Growth Advantage in Low Folate 1

Wei-Yong Zhu; Peter W. Melera

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The Addition of Adenovirus Type 5 Region E3 Enables Calydon Virus 787 to Eliminate Distant Prostate Tumor Xenografts

De-Chao Yu; Yu Chen; Monica Seng; Jeanette Dilley; Daniel R. Henderson

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Overexpression of Ribonucleotide Reductase as a Mechanism of Resistance to 2,2-Difluorodeoxycytidine in the Human KB Cancer Cell Line 1

Yih-Gang Goan; Bingsen Zhou; Edward Hu; Shu Mi; Yun Yen

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Activation of the PI3′K-AKT Pathway Masks the Proapoptotic Effects of Farnesyltransferase Inhibitors 1

Wei Du; Aixue Liu; George C. Prendergast

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Frequent Frameshift Mutations of the TCF-4 Gene in Colorectal Cancers with Microsatellite Instability 1

Alex Duval; Jacqueline Gayet; Xiao-Ping Zhou; Barry Iacopetta; Gilles Thomas; Richard Hamelin

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Four New Colon Cancer Susceptibility Loci, Scc6 to Scc9 in the Mouse 1

Tom van Wezel; Claudia A. L. Ruivenkamp; Alphons P. M. Stassen; Corina J. A. Moen; Peter Demant

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Heat Shock Cognate 70 Mutations in Sporadic Breast Carcinoma 1

Christopher J. Bakkenist; John Koreth; Cory S. M. Williams; Nicholas C. A. Hunt; James O. McGee

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Absence of Genetic Alteration at Codon 531 of the Human c-src Gene in 479 Advanced Colorectal Cancers from Japanese and Caucasian Patients 1

Yataro Daigo; Yoichi Furukawa; Teru Kawasoe; Hideyuki Ishiguro; Manabu Fujita; Sachiko Sugai; Shoji Nakamori; Gerrit-Jan Liefers; Rob A. E. M. Tollenaar; Cornelis J. H. van de Velde; Yusuke Nakamura

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Correlation between Expression of the Matrix Metalloproteinase-1 Gene in Ovarian Cancers and an Insertion/Deletion Polymorphism in Its Promoter Region 1

Yasunobu Kanamori; Mieko Matsushima; Takeo Minaguchi; Kanji Kobayashi; Satoru Sagae; Ryuichi Kudo; Naoki Terakawa; Yusuke Nakamura

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Reactivation of Insulin-like Growth Factor Binding Protein 2 Expression in Glioblastoma Multiforme: A Revelation by Parallel Gene Expression Profiling 1

Gregory N. Fuller; Chang Hun Rhee; Kenneth R. Hess; Laura S. Caskey; Ruoping Wang; Janet M. Bruner; W. K. Alfred Yung; Wei Zhang

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Distinct Expression Patterns of the p53-Homologue p73 in Malignant and Normal Hematopoiesis Assessed by a Novel Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Protein Analysis 1

Uwe R. Peters; Mario P. Tschan; Karl A. Kreuzer; Gökben Baskaynak; Ulrich Lass; Andreas Tobler; Martin F. Fey; Christian A. Schmidt

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The Mouse Bcrp1/Mxr/Abcp Gene: Amplification and Overexpression in Cell Lines Selected for Resistance to Topotecan, Mitoxantrone, or Doxorubicin 1

John D. Allen; Remco F. Brinkhuis; Jan Wijnholds; Alfred H. Schinkel

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A Single Targeted Ets2 Allele Restricts Development of Mammary Tumors in Transgenic Mice 1

Nickolay Neznanov; Albert K. Man; Hideyuki Yamamoto; Craig A. Hauser; Robert D. Cardiff; Robert G. Oshima

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Wild-Type p53 Induction Mediated by Replication-deficient Adenoviral Vectors 1

Christina R. McPake; Sheetal Shetty; Geoffrey R. Kitchingman; Linda C. Harris

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Prostase/KLK-L1 Is a New Member of the Human Kallikrein Gene Family, Is Expressed in Prostate and Breast Tissues, and Is Hormonally Regulated

George M. Yousef; Christina V. Obiezu; Liu-Ying Luo; Margot H. Black; Eleftherios P. Diamandis

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Frequent Somatic Mutations of the β-Catenin Gene in Intestinal-Type Gastric Cancer 1

Won Sang Park; Ro Ra Oh; Jik Young Park; Sug Hyung Lee; Min Sun Shin; Young Sil Kim; Su Young Kim; Hyun Kyung Lee; Pum Joon Kim; Seong Taek Oh; Nam Jin Yoo; Jung Young Lee

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AF17q25, a Putative Septin Family Gene, Fuses the MLL Gene in Acute Myeloid Leukemia with t(11;17)(q23;q25)1

Tomohiko Taki; Hiroaki Ohnishi; Kenji Shinohara; Masahiro Sako; Fumio Bessho; Masayoshi Yanagisawa; Yasuhide Hayashi

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Sp3, but not Sp1, Mediates the Transcriptional Activation of the p21/WAF1/Cip1 Gene Promoter by Histone Deacetylase Inhibitor 1

Yoshihiro Sowa; Tetsuro Orita; Sachie Minamikawa-Hiranabe; Takakazu Mizuno; Hitoshi Nomura; Toshiyuki Sakai

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Biochemistry

Mode of Action of a New Indolocarbazole Anticancer Agent, J-107088, Targeting Topoisomerase I

Tomoko Yoshinari; Mitsuru Ohkubo; Kazuhiro Fukasawa; Shin-ichirou Egashira; Yoshikazu Hara; Mami Matsumoto; Kiyoshi Nakai; Hiroharu Arakawa; Hajime Morishima; Susumu Nishimura

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Carcinogenesis

Murine Mammary Gland Carcinogenesis Is Critically Dependent on Progesterone Receptor Function 1

John P. Lydon; Gouqing Ge; Francis S. Kittrell; Daniel Medina; Bert W. O’Malley

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Patterns of DNA Adduct Formation in Liver and Mammary Epithelial Cells of Rats Treated with 7,12-Dimethylbenz(a)anthracene, and Selective Effects of Chemopreventive Agents 1

Alberto Izzotti; Anna Camoirano; Cristina Cartiglia; Clinton J. Grubbs; Ronald A. Lubet; Gary J. Kelloff; Silvio De Flora

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Clinical Investigations

Loss of PTEN Expression in Paraffin-embedded Primary Prostate Cancer Correlates with High Gleason Score and Advanced Stage 1

Máirín E. McMenamin; Peggy Soung; Sauni Perera; Irving Kaplan; Massimo Loda; William R. Sellers

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Effect of c-kit Mutation on Prognosis of Gastrointestinal Stromal Tumors 1

Masahiko Taniguchi; Toshirou Nishida; Seiichi Hirota; Koji Isozaki; Toshinori Ito; Taisei Nomura; Hikaru Matsuda; Yukihiko Kitamura

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High Telomerase Reverse Transcriptase (hTERT) Messenger RNA Level Correlates with Tumor Recurrence in Patients with Favorable Histology Wilms’ Tumor 1

Jeffrey S. Dome; Seung Chung; Tracy Bergemann; Christopher B. Umbricht; Motoyasu Saji; Lisa A. Carey; Paul E. Grundy; Elizabeth J. Perlman; Norman E. Breslow; Saraswati Sukumar

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Endocrinology

The Interaction of Raloxifene and the Active Metabolite of the Antiestrogen EM-800 (SC 5705) with the Human Estrogen Receptor 1

Jennifer I. MacGregor Schafer; Hong Liu; Debra A. Tonetti; V. Craig Jordan

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Altered Ligand Binding by Insulin-like Growth Factor II/Mannose 6-Phosphate Receptors Bearing Missense Mutations in Human Cancers 1

Gayathri R. Devi; Angus T. De Souza; James C. Byrd; Randy L. Jirtle; Richard G. MacDonald

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Epidemiology and Prevention

Well-done, Grilled Red Meat Increases the Risk of Colorectal Adenomas 1

Rashmi Sinha; Wong Ho Chow; Martin Kulldorff; John Denobile; James Butler; Montserrat Garcia-Closas; Rusty Weil; Robert N. Hoover; Nathaniel Rothman

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Experimental Therapeutics

Inhibition of Cancer Cell Growth by Polyinosinic-Polycytidylic Acid/Cationic Liposome Complex: A New Biological Activity

Kazuko Hirabayashi; Junichi Yano; Toshihiko Inoue; Tohru Yamaguchi; Kazuaki Tanigawara; Gerald E. Smyth; Kouichi Ishiyama; Tadaaki Ohgi; Kiyoshi Kimura; Tatsuro Irimura

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Photofrin-mediated Photodynamic Therapy Induces Vascular Occlusion and Apoptosis in a Human Sarcoma Xenograft Model 1

Brett W. Engbrecht; Chandrakala Menon; Alexander V. Kachur; Stephen M. Hahn; Douglas L. Fraker

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Apoptosis Induction by a Novel Anti-Prostate Cancer Compound, BMD188 (a Fatty Acid-containing Hydroxamic Acid), Requires the Mitochondrial Respiratory Chain 1

Bindu Joshi; Li Li; Bonita G. Taffe; Zhenyu Zhu; Sharon Wahl; Hongsheng Tian; Edgar Ben-Josef; John D. Taylor; Arthur T. Porter; Dean G. Tang

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Increased Cyclooxygenase-2 Expression in Human Pancreatic Carcinomas and Cell Lines: Growth Inhibition by Nonsteroidal Anti-Inflammatory Drugs 1

Miguel A. Molina; Marta Sitja-Arnau; Michael G. Lemoine; Marsha L. Frazier; Frank A. Sinicrope

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Direct Demonstration in Synthetic Oligonucleotides that N,N′-Bis(2-chloroethyl)-nitrosourea Cross-Links N¹ of Deoxyguanosine to N³ of Deoxycytidine on Opposite Strands of Duplex DNA 1

Paula L. Fischhaber; Anna S. Gall; James A. Duncan; Paul B. Hopkins

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p53 Selective and Nonselective Replication of an E1B-deleted Adenovirus in Hepatocellular Carcinoma 1

Charles M. Vollmer; Antoni Ribas; Lisa H. Butterfield; Vivian B. Dissette; Kahlil J. Andrews; Fritz C. Eilber; Lara D. Montejo; Angela Y. Chen; Billy Hu; John A. Glaspy; William H. McBride; James S. Economou

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Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine 1

Jann N. Sarkaria; Ericka C. Busby; Randal S. Tibbetts; Pia Roos; Yoichi Taya; Larry M. Karnitz; Robert T. Abraham

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Glioma Cells Release Excitotoxic Concentrations of Glutamate 1

Zu-Cheng Ye; Harald Sontheimer

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Hybrid Polar Histone Deacetylase Inhibitor Induces Apoptosis and CD95/CD95 Ligand Expression in Human Neuroblastoma 1

Richard D. Glick; Steven L. Swendeman; Dennis C. Coffey; Richard A. Rifkind; Paul A. Marks; Victoria M. Richon; Michael P. La Quaglia

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Pretargeting of Renal Cell Carcinoma: Improved Tumor Targeting with a Bivalent Chelate 1

Otto C. Boerman; Marion H. G. C. Kranenborg; Egbert Oosterwijk; Gary L. Griffiths; William J. McBride; Wim J. G. Oyen; Mirjam de Weijert; Jeannette Oosterwijk-Wakka; Hans J. Hansen; Frans H. M. Corstens

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Decrease in Susceptibility Toward Induction of Apoptosis and Alteration in G₁ Checkpoint Function as Determinants of Resistance of Human Lung Cancer Cells against the Antisignaling Drug UCN-01 (7-Hydroxystaurosporine)

Kazuyo Sugiyama; Tadakazu Akiyama; Makiko Shimizu; Tatsuya Tamaoki; Carol Courage; Andreas Gescher; Shiro Akinaga

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Tumor Biology

Protein Kinase C Lies on the Signaling Pathway for Vascular Endothelial Growth Factor-mediated Tumor Development and Angiogenesis

Hitoshi Yoshiji; Shigeki Kuriyama; D. Kirk Ways; Junichi Yoshii; Yoji Miyamoto; Mitsuhiro Kawata; Yasuhide Ikenaka; Hirohisa Tsujinoue; Toshiya Nakatani; Masabumi Shibuya; Hiroshi Fukui

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The Role of Hyaluronan and Interleukin 8 in the Migration of Chronic Lymphocytic Leukemia Cells within Lymphoreticular Tissues 1

Kathleen J. Till; Mirko Zuzel; John C. Cawley

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CD44 Stimulation Induces Integrin-mediated Adhesion of Colon Cancer Cell Lines to Endothelial Cells by Up-Regulation of Integrins and c-Met and Activation of Integrins 1

Takeshi Fujisaki; Yoshiya Tanaka; Koichi Fujii; Shinichiro Mine; Kazuyoshi Saito; Shinwa Yamada; Uki Yamashita; Tatsuro Irimura; Sumiya Eto

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Cloning of Tumor-associated Differentially Expressed Gene-14, a Novel Serine Protease Overexpressed by Ovarian Carcinoma

Lowell J. Underwood; Hirotoshi Tanimoto; Yinxiang Wang; Kazushi Shigemasa; Tim H. Parmley; Timothy J. O’Brien

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Regulation of the Urokinase-type Plasminogen Activator System by the von Hippel-Lindau Tumor Suppressor Gene 1

Maartje Los; Saida Zeamari; John A. Foekens; Martijn F. B. G. Gebbink; Emile E. Voest

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Inhibition of Nuclear Factor-κB Activation Confers Sensitivity to Tumor Necrosis Factor-α by Impairment of Cell Cycle Progression in Human Glioma Cells 1

Goro Otsuka; Takashi Nagaya; Kiyoshi Saito; Masaaki Mizuno; Jun Yoshida; Hisao Seo

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Osteonectin Promotes Prostate Cancer Cell Migration and Invasion: A Possible Mechanism for Metastasis to Bone 1

Karin Jacob; Mukta Webber; Dafna Benayahu; Hynda K. Kleinman

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Cellular Membrane Permeability of Anthracyclines Does Not Correlate with Their Delivery in a Tissue-isolated Tumor 1

Marc Heijn; Sylvie Roberge; Rakesh K. Jain

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Identification of Bladder Tumor-derived Hyaluronidase: Its Similarity to HYAL1 1

Vinata B. Lokeshwar; Marvin J. Young; Gulten Goudarzi; Naoko Iida; Ashley I. Yudin; Gary N. Cherr; Marie G. Selzer

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Letters to the Editor

Correspondence re: Y. Chen et al., DNA Vaccines Encoding Full-Length or Truncated Neu Induce Protective Immunity against Neu-expressing Mammary Tumors. Cancer Res., 58: 1965–1971, 1998.

Roberta De Vecchi; Serenella M. Pupa; Sylvie Ménard; Pier-Luigi Lollini

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Errata

July 1, 1999 Cancer Research cover legend

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Perspectives in Cancer Research

Advances in Brief

Biochemistry

Carcinogenesis

Clinical Investigations

Endocrinology

Epidemiology and Prevention

Experimental Therapeutics

Tumor Biology

Letters to the Editor

Errata

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