(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Transformation and Morphological Changes of Murine L Cells by Transfection with a Mutated Form of β-Catenin 1

Yutaka Nagasawa; Yasuo Miyoshi; Kyoko Iwao; Yasuhisa Shinomura; Yuji Matsuzawa; Yusuke Nakamura

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Enhanced Phosphorylation of p53 Serine 18 following DNA Damage in DNA-dependent Protein Kinase Catalytic Subunit-deficient Cells

Ryoko Araki; Ryutaro Fukumura; Akira Fujimori; Yoichi Taya; Yosef Shiloh; Akihiro Kurimasa; Sandeep Burma; Gloria C. Li; David J. Chen; Koki Sato; Yuko Hoki; Kouichi Tatsumi; Masumi Abe

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BRCA2 Is Required for Ionizing Radiation-induced Assembly of Rad51 Complex in Vivo1

Shyng-Shiou F. Yuan; Sou-Ying Lee; Gang Chen; Meihua Song; Gail E. Tomlinson; Eva Y-H. P. Lee

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Suppression of Prostate Cancer Invasive Potential and Matrix Metalloproteinase Activity by E-Cadherin Transfection 1

Jun Luo; David M. Lubaroff; Mary J. C. Hendrix

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Hormonal Treatment after Cytotoxic Therapy Stimulates Recovery of Spermatogenesis 1

Marvin L. Meistrich; Gene Wilson; Ilpo Huhtaniemi

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Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-Δ32 Mutation 1

Michael Dean; Lisa P. Jacobson; Glen McFarlane; Joseph B. Margolick; Frank J. Jenkins; O. M. Zack Howard; Hui-Fang Dong; James J. Goedert; Susan Buchbinder; Edward Gomperts; David Vlahov; Joost J. Oppenheim; Stephen J. O’Brien; Mary Carrington

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Caspase Inhibition in Camptothecin-treated U-937 Cells Is Coupled with a Shift from Apoptosis to Transient G₁ Arrest Followed by Necrotic Cell Death 1

Alain-Théophile Sané; Richard Bertrand

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Unbalanced Germ-Line Expression of hMLH1 and hMSH2 Alleles in Hereditary Nonpolyposis Colorectal Cancer 1

Maria Cristina Curia; Raffaele Palmirotta; Gitana Aceto; Luca Messerini; Maria Concetta Verì; Stefania Crognale; Rosa Valanzano; Ferdinando Ficari; Pierluigi Fracasso; Vittoria Stigliano; Francesco Tonelli; Vincenzo Casale; Fiorella Guadagni; Pasquale Battista; Renato Mariani-Costantini; Alessandro Cama

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Multiple Regions of Chromosome 4 Demonstrating Allelic Losses in Breast Carcinomas 1

Narayan Shivapurkar; Sanjay Sood; Ignacio I. Wistuba; Arvind K. Virmani; Anirban Maitra; Sara Milchgrub; John D. Minna; Adi F. Gazdar

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Regulation of Cell Growth and Cyclin D1 Expression by the Constitutively Active FRAP-p70^s6K Pathway in Human Pancreatic Cancer Cells 1

Martin Grewe; Frank Gansauge; Roland M. Schmid; Guido Adler; Thomas Seufferlein

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Expression of Insulin-like Growth Factor-1 Receptor in Synovial Sarcoma: Association with an Aggressive Phenotype 1

Yuntao Xie; Björn Skytting; Gunnar Nilsson; Bertha Brodin; Olle Larsson

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Interaction of Adeno-associated Virus Rep78 with p53: Implications in Growth Inhibition 1

Ramesh B. Batchu; Masood A. Shammas; Jing Yi Wang; Nikhil C. Munshi

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The Chromosome 10 Monosomy Common in Human Melanomas Results from the Loss of Two Separate Tumor Suppressor Loci 1

Gavin P. Robertson; Rudolf A. Herbst; Motoo Nagane; H-J. Su Huang; Webster K. Cavenee

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Stereochemistry of Metabolites of a Tobacco-specific Lung Carcinogen in Smokers’ Urine 1

Steven G. Carmella; Ming Ye; Pramod Upadhyaya; Stephen S. Hecht

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Carcinogenesis

Specific p53 Gene Mutations in Urinary Bladder Epithelium after the Chernobyl Accident 1

Shinji Yamamoto; Alina Romanenko; Min Wei; Chikayoshi Masuda; Wadim Zaparin; Wladimir Vinnichenko; Alexander Vozianov; Chyi Chia R. Lee; Keiichirou Morimura; Hideki Wanibuchi; Mitsuhiro Tada; Shoji Fukushima

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Difluoromethylornithine Chemoprevention of Epidermal Carcinogenesis in K14-HPV16 Transgenic Mice 1

Jeffrey M. Arbeit; Rebeccah R. Riley; Bing Huey; Carl Porter; Gary Kelloff; Ronald Lubet; Jerrold M. Ward; Dan Pinkel

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Elevated Mutant Frequencies in Lymphoid Tissues Persist throughout Plasmacytoma Development in BALB/c.λLIZ Mice 1

Klaus Felix; Kevin A. Kelliher; Georg-Wilhelm Bornkamm; Siegfried Janz

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Exposure of Sprague-Dawley Rats to a 50-Hertz, 100-μTesla Magnetic Field for 27 Weeks Facilitates Mammary Tumorigenesis in the 7,12-Dimethylbenz[a]-anthracene Model of Breast Cancer 1

Susanne Thun-Battersby; Meike Mevissen; Wolfgang Löscher

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High Frequency and Heterogeneous Distribution of p53 Mutations in Aflatoxin B₁-induced Mouse Lung Tumors 1

Andrew S. Tam; Julie F. Foley; Theodora R. Devereux; Robert R. Maronpot; Thomas E. Massey

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Quinol-Glutathione Conjugate-induced Mutation Spectra in the supF Gene Replicated in Human AD293 Cells and Bacterial MBL50 Cells 1

Jeongmi K. Jeong; Gerald N. Wogan; Serrine S. Lau; Terrence J. Monks

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Endocrinology

Idoxifene Antagonizes Estradiol-dependent MCF-7 Breast Cancer Xenograft Growth through Sustained Induction of Apoptosis

Stephen R. D. Johnston; Irene M. Boeddinghaus; Sharon Riddler; Ben P. Haynes; Ian R. Hardcastle; Martin Rowlands; Rachel Grimshaw; Michael Jarman; Mitch Dowsett

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Differential Regulation of Somatostatin Receptor Type 2 (sst 2) Expression in AR4-2J Tumor Cells Implanted into Mice during Octreotide Treatment 1

Sylvie Froidevaux; Edith Hintermann; Michael Török; Helmut R. Mäcke; Christoph Beglinger; Alex N. Eberle

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Epidemiology and Prevention

Reproductive Factors of Ovarian and Endometrial Cancer Risk in a High Fertility Population in Mexico

Eduardo Salazar-Martinez; Eduardo Cesar Lazcano-Ponce; Guillermo Gonzalez Lira-Lira; Pedro Escudero-De los Rios; Jorge Salmeron-Castro; Mauricio Hernandez-Avila

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Experimental Therapeutics

DNA Damage Increases Sensitivity to Vinca Alkaloids and Decreases Sensitivity to Taxanes through p53-dependent Repression of Microtubule-associated Protein 4 1

Christine C. Zhang; Jin-Ming Yang; Judy Bash-Babula; Eileen White; Maureen Murphy; Arnold J. Levine; William N. Hait

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Cell Cycle Modulation by a Multitargeted Antifolate, LY231514, Increases the Cytotoxicity and Antitumor Activity of Gemcitabine in HT29 Colon Carcinoma

John L. Tonkinson; John F. Worzalla; Chi-Hse Teng; Laurane G. Mendelsohn

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Tumor Radiosensitization by Sustained Intratumoral Release of Bromodeoxyuridine

Annie Doiron; Donald T. T. Yapp; Marina Olivares; Julian X. X. Zhu; Shirley Lehnert

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Enhanced Amsacrine-induced Mutagenesis in Plateau-Phase Chinese Hamster Ovary Cells, with Targeting of +1 Frameshifts to Free 3′ Ends of Topoisomerase II Cleavable Complexes 1

Kathleen Patteson; Peng Wang; Lawrence F. Povirk

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Tethering a Type IB Topoisomerase to a DNA Site by Enzyme Fusion to a Heterologous Site-selective DNA-binding Protein Domain 1

Giovanni Luca Beretta; Monica Binaschi; Emanuela Zagni; Luisa Capuani; Giovanni Capranico

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Immunology

Interleukin 17, a T-cell-derived Cytokine, Promotes Tumorigenicity of Human Cervical Tumors in Nude Mice 1

Eric Tartour; François Fossiez; Isabelle Joyeux; Annie Galinha; Alain Gey; Emmanuel Claret; Xavier Sastre-Garau; Jérôme Couturier; Veronique Mosseri; Virginie Vives; Jacques Banchereau; Wolf H. Fridman; John Wijdenes; Serge Lebecque; Catherine Sautèes-Fridman

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Molecular Biology and Genetics

The Cell Cycle Regulator p27^kip1 Contributes to Growth and Differentiation of Osteoblasts 1

Hicham Drissi; Dennet Hushka; Fauzia Aslam; Que Nguyen; Elizabeth Buffone; Andrew Koff; André J. van Wijnen; Jane B. Lian; Janet L. Stein; Gary S. Stein

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Nonrandom Degradation of DNA in Human Leukemic Cells during Radiation-induced Apoptosis 1

Robert G. Dullea; Jeanne F. Robinson; Joel S. Bedford

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The Dermatofibrosarcoma Protuberans-associated Collagen Type Iα1/Platelet-derived Growth Factor (PDGF) B-Chain Fusion Gene Generates a Transforming Protein That Is Processed to Functional PDGF-BB 1

Akira Shimizu; Kevin P. O’Brien; Tobias Sjöblom; Kristian Pietras; Elisabeth Buchdunger; V. Peter Collins; Carl-Henrik Heldin; Jan P. Dumanski; Arne Östman

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Lymph Node Metastasis Is Associated with Allelic Loss on Chromosome 13q12–13 in Esophageal Squamous Cell Carcinoma¹

Hideki Harada; Hisashi Tanaka; Yutaka Shimada; Masayuki Shinoda; Masayuki Imamura; Kanji Ishizaki

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Concurrent DNA Hypermethylation of Multiple Genes in Acute Myeloid Leukemia

John R. Melki; Paul C. Vincent; Susan J. Clark

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Bdp, a New Member of a Family of DNA-binding Proteins, Associates with the Retinoblastoma Gene Product 1

Shin-ichiro Numata; Pier Paolo Claudio; Charity Dean; Antonio Giordano; Carlo M. Croce

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Identification of a Gene Encoding a Human Oxysterol-binding Protein-Homologue: A Potential General Molecular Marker for Blood Dissemination of Solid Tumors

Marcia V. Fournier; Fernanda C. Guimaraes; Marcos E. M. Paschoal; Lucienne V. Ronco; Maria da Gloria Costa Carvalho; Arthur B. Pardee

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Tumor Biology

A Novel Disintegrin Salmosin Inhibits Tumor Angiogenesis 1

In-Cheol Kang; Young-Don Lee; Doo-Sik Kim

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A Senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents 1

Bey-Dih Chang; Eugenia V. Broude; Milos Dokmanovic; Hongming Zhu; Adam Ruth; Yongzhi Xuan; Eugene S. Kandel; Ekkehart Lausch; Konstantin Christov; Igor B. Roninson

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Human Natural Immunoglobulin M Antibodies Induce Apoptosis of Human Neuroblastoma Cells by Binding to a M_r 260,000 Antigen 1

Kerstin David; Markus W. Ollert; Caren Vollmert; Sven Heiligtag; Britta Eickhoff; Rudolf Erttmann; Reinhard Bredehorst; Carl-Wilhelm Vogel

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Taxane-induced Apoptosis Decompresses Blood Vessels and Lowers Interstitial Fluid Pressure in Solid Tumors: Clinical Implications 1

Genevièeve Griffon-Etienne; Yves Boucher; Christian Brekken; Herman D. Suit; Rakesh K. Jain

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Restoration of Wild-Type p16 Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Human Gliomas 1

Hironobu Harada; Kou Nakagawa; Shinji Iwata; Masahiro Saito; Yoshiaki Kumon; Saburo Sakaki; Kohji Sato; Katsuyuki Hamada

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Frequent Loss of Expression of the Cyclin-dependent Kinase Inhibitor p27 in Epithelial Ovarian Cancer 1

Valeria Masciullo; Alessandro Sgambato; Carmen Pacilio; Bruna Pucci; Gabriella Ferrandina; Juan Palazzo; Arnaldo Carbone; Achille Cittadini; Salvatore Mancuso; Giovanni Scambia; Antonio Giordano

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Transformation Blocks Differentiation-induced Inhibition of Serum Response Factor Interactions with Serum Response Elements 1

Wei Ding; Michael M. Witte; Robert E. Scott

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Induction of a Functional Vitamin D Receptor in all-trans-Retinoic Acid-induced Monocytic Differentiation of M2-type Leukemic Blast Cells 1

Rossella Manfredini; Francesca Trevisan; Alexis Grande; Enrico Tagliafico; Monica Montanari; Roberto Lemoli; Giuseppe Visani; Sante Tura; Stefano Ferrari; Sergio Ferrari

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Eukaryotic Expression Cloning with an Antimetastatic Monoclonal Antibody Identifies a Tetraspanin (PETA-3/CD151) as an Effector of Human TumorCell Migration and Metastasis 1

Jacqueline E. Testa; Peter C. Brooks; Jian-Min Lin; James P. Quigley

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Acquisition of Neuroendocrine Characteristics by Prostate Tumor Cells Is Reversible: Implications for Prostate Cancer Progression 1

Michael E. Cox; Paul D. Deeble; Saquib Lakhani; Sarah J. Parsons

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Defective G₁-S Cell Cycle Checkpoint Function Sensitizes Cells to Microtubule Inhibitor-induced Apoptosis 1

Zoe A. Stewart; Deborah Mays; Jennifer A. Pietenpol

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Posttranslational Mechanisms Contribute to the Suppression of Specific Cyclin: CDK Complexes by All-Trans Retinoic Acid in Human Bronchial Epithelial Cells 1

Naoko Sueoka; Ho-Young Lee; Garrett L. Walsh; Waun Ki Hong; Jonathan M. Kurie

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Meeting Report

Eighth International Workshop on Ataxia-Telangiectasia (ATW8)

Martin F. Lavin; Patrick Concannon; Richard A. Gatti

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Advances in Brief

Carcinogenesis

Endocrinology

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Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

Meeting Report

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