(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Quantitation of MYC Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-PCR Assay 1

Ivan Bièche; Ingrid Laurendeau; Sengül Tozlu; Martine Olivi; Dominique Vidaud; Rosette Lidereau; Michel Vidaud

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Inhibitors of Histone Deacetylase Relieve ETO-mediated Repression and Induce Differentiation of AML1-ETO Leukemia Cells

Jianxiang Wang; Yogen Saunthararajah; Robert L. Redner; Johnson M. Liu

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Molecular Cloning and Functional Analysis of the Mouse Homologue of the KILLER/DR5 Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Death Receptor 1

Gen Sheng Wu; Timothy F. Burns; Yi Zhan; Emad S. Alnemri; Wafik S. El-Deiry

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Recurrent Involvement of 2p23 in Inflammatory Myofibroblastic Tumors

Constance A. Griffin; Anita L. Hawkins; Cecily Dvorak; Carol Henkle; Tara Ellingham; Elizabeth J. Perlman

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The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences 1

Akira Shimada; Shunsuke Kato; Kentaro Enjo; Motonobu Osada; Yoji Ikawa; Kenji Kohno; Masuo Obinata; Ryunosuke Kanamaru; Shuntaro Ikawa; Chikashi Ishioka

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Human Prostate Cancer Expresses the Low Affinity Insulin-like Growth Factor Binding Protein IGFBP-rP1 1

Armelle Degeorges; Fuan Wang; Henry F. Frierson, Jr.; Arun Seth; Leland W. K. Chung; Robert A. Sikes

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Elevated and Biallelic Expression of p73 Is Associated with Progression of Human Bladder Cancer

Sung-Gil Chi; Sung-Goo Chang; Sun-Ju Lee; Choong-Hyun Lee; Jin Il Kim; Jae-Hoon Park

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Prognostic Significance of Polo-like Kinase (PLK) Expression in Squamous Cell Carcinomas of the Head and Neck 1

Rainald Knecht; Robert Elez; Martin Oechler; Christine Solbach; Christoph von Ilberg; Klaus Strebhardt

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Eponemycin Exerts Its Antitumor Effect through the Inhibition of Proteasome Function 1

Lihao Meng; Benjamin H. B. Kwok; Ny Sin; Craig M. Crews

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Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity

Alan Melcher; Stephen Todryk; Andrew Bateman; Heung Chong; Nicholas R Lemoine; Richard G Vile

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Identification of a Region of Frequent Loss of Heterozygosity at 11q24 in Colorectal Cancer

Kate C. Connolly; Hani Gabra; Christopher J. Millwater; Karen J. Taylor; Genevieve J. Rabiasz; J. E. Vivienne Watson; John F. Smyth; Andrew H. Wyllie; Duncan I. Jodrell

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Identification of a Transactivation Activity in the COOH-Terminal Region of p73 Which Is Impaired in the Naturally Occurring Mutants Found inHuman Neuroblastomas 1

Naoyuki Takada; Toshinori Ozaki; Shingo Ichimiya; Satoru Todo; Akira Nakagawara

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Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt 1

Miroslaw Majewski; Malgorzata Nieborowska-Skorska; Paolo Salomoni; Artur Slupianek; Krzysztof Reiss; Rossana Trotta; Bruno Calabretta; Tomasz Skorski

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Molecular Cloning and Expression of an Alternative hKLK3 Transcript Coding for a Variant Protein of Prostate-specific Antigen 1

Nathalie Heuzé; Sophie Olayat; Ninette Gutman; Marie-Louise Zani; Yves Courty

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CYP17 and Breast Cancer Risk: The Polymorphism in the 5′ Flanking Area of the Gene Does Not Influence Binding to Sp-1 1

Vessela Nedelcheva Kristensen; Ellen K. Haraldsen; Kristin B. Anderson; P. E. Lønning; Bjørn Erikstein; Rolf Kåresen; Odd S. Gabrielsen; Anne-Lise Børresen-Dale

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Implication of p53 in Growth Arrest and Apoptosis Induced by the Synthetic Retinoid CD437 in Human Lung Cancer Cells 1

Shi-Yong Sun; Ping Yue; Gen Sheng Wu; Wafik S. El-Deiry; Braham Shroot; Waun K. Hong; Reuben Lotan

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Optimizing Syngeneic Orthotopic Murine Bladder Cancer (MB49)1

Jan H. Günther; Andreas Jurczok; Tina Wulf; Sven Brandau; Irina Deinert; Dieter Jocham; Andreas Böhle

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Dead or Dying: Necrosis versus Apoptosis in Caspase-deficient Human RenalCell Carcinoma 1

Vladimir Kolenko; Robert G. Uzzo; Ronald Bukowski; Neil H. Bander; Andrew C. Novick; Eric D. Hsi; James H. Finke

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Transcriptional Up-Regulation of Paxillin Expression by Heregulin in Human Breast Cancer Cells 1

Ratna Vadlamudi; Liana Adam; Ben Tseng; Louis Costa; Rakesh Kumar

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Biochemistry

Antagonism of p53-dependent Apoptosis by Mitogen Signals 1

Mira Hong; Ming-Derg Lai; Young-Sun Lin; Ming-Zong Lai

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Intercalation into DNA Is Not Required for Inhibition of Topoisomerase I by Indolocarbazole Antitumor Agents 1

Christian Bailly; Laurent Dassonneville; Pierre Colson; Claude Houssier; Kazuhiro Fukasawa; Susumu Nishimura; Tomoko Yoshinari

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Carcinogenesis

Blocking Transforming Growth Factor β Signaling in Transgenic Epidermis Accelerates Chemical Carcinogenesis: A Mechanism Associated with Increased Angiogenesis 1

Cindy Go; Ping Li; Xiao-Jing Wang

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NG2 Proteoglycan-binding Peptides Target Tumor Neovasculature 1

Michael A. Burg; Renata Pasqualini; Wadih Arap; Erkki Ruoslahti; William B. Stallcup

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Effects of Chronic Low-Dose Ultraviolet B Radiation on DNA Damage and Repair in Mouse Skin 1

David L. Mitchell; Rüdiger Greinert; Frank R. de Gruijl; Kees L. H. Guikers; Eckhard W. Breitbart; Michelle Byrom; Michelle M. Gallmeier; Megan G. Lowery; Beate Volkmer

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Clinical Investigations

Expression of Cyclin A in Soft Tissue Sarcomas Correlates with Tumor Aggressiveness 1

Riikka Leena Huuhtanen; Carl Peter Blomqvist; Tom Ove Böhling; Tom Anders Wiklund; Erkki Juhani Tukiainen; Martti Virolainen; Bernhard Tribukait; Leif Christer Andersson

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Endocrinology

The Phosphatidylinositol 3′-kinase Pathway Is a Dominant Growth Factor-activated Cell Survival Pathway in LNCaP Human Prostate Carcinoma Cells

Jianqing Lin; Rosalyn M. Adam; Eric Santiestevan; Michael R. Freeman

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N-myc Regulation of Type I Insulin-like Growth Factor Receptor in a Human Neuroblastoma Cell Line 1

Daniel Chambéry; Sarah Mohseni-Zadeh; Brigitte de Gallé; Sylvie Babajko

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Epidemiology and Prevention

Candidate Genetic Modifiers of Individual Susceptibility to Renal Cell Carcinoma: A Study of Polymorphic Human Xenobiotic-metabolizing Enzymes 1

Sandrine Longuemaux; Claudine Deloménie; Catherine Gallou; Arnaud Méjean; Monique Vincent-Viry; Raymonde Bouvier; Dominique Droz; Rajagopal Krishnamoorthy; Marie-Madeleine Galteau; Claudine Junien; Christophe Béroud; Jean-Marie Dupret

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Experimental Therapeutics

Carcinoembryonic Antigen (CEA)-specific T-Cell Activation in Colon Carcinoma Induced by Anti-CD3×Anti-CEA Bispecific Diabodies and B7×Anti-CEA Bispecific Fusion Proteins 1

Philipp Holliger; Oliver Manzke; Mary Span; Robert Hawkins; Bernd Fleischmann; Liu Qinghua; Jürgen Wolf; Volker Diehl; Olivier Cochet; Greg Winter; Heribert Bohlen

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Tumor Pretargeting with Avidin Improves the Therapeutic Index of Biotinylated Tumor Necrosis Factor α in Mouse Models 1

Anna Gasparri; Monica Moro; Flavio Curnis; Angelina Sacchi; Stefano Pagano; Fabrizio Veglia; Giulia Casorati; Antonio G. Siccardi; Paolo Dellabona; Angelo Corti

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Differential Effects of a Stem Cell Factor-Immunoglobulin Fusion Protein on Malignant and Normal Hematopoietic Cells 1

Ulrike Erben; Eckhard Thiel; Michael Notter

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KF25706, a Novel Oxime Derivative of Radicicol, Exhibits in Vivo Antitumor Activity via Selective Depletion of Hsp90 Binding Signaling Molecules

Shiro Soga; Leonard M. Neckers; Theodor W. Schulte; Yukimasa Shiotsu; Kazuhito Akasaka; Hiroaki Narumi; Tsutomu Agatsuma; Yoji Ikuina; Chikara Murakata; Tatsuya Tamaoki; Shiro Akinaga

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Homocamptothecin, an E-Ring Modified Camptothecin with Enhanced Lactone Stability, Retains Topoisomerase I-targeted Activity andAntitumor Properties 1

Laurence Lesueur-Ginot; Danièle Demarquay; Robert Kiss; Philip G. Kasprzyk; Laurent Dassonneville; Christian Bailly; José Camara; Olivier Lavergne; Dennis C. H. Bigg

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Antitumor Activity of P-4055 (Elaidic Acid-Cytarabine) Compared to Cytarabine in Metastatic and s.c. Human Tumor Xenograft Models

Knut Breistøl; Jan Balzarini; Marit Liland Sandvold; Finn Myhren; Marita Martinsen; Erik De Clercq; Øystein Fodstad

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Immunology

Primary Chemically Induced Tumors Induce Profound Immunosuppression Concomitant with Apoptosis and Alterations in Signal Transduction in T Cells and NK Cells 1

Shigetoshi Horiguchi; Max Petersson; Tsutomu Nakazawa; Minoru Kanda; Arnold H. Zea; Augusto C. Ochoa; Rolf Kiessling

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Molecular Biology and Genetics

p16/pRb Pathway Alterations Are Required for Bypassing Senescence in Human Prostate Epithelial Cells 1

David F. Jarrard; Somdatta Sarkar; Yan Shi; Thomas R. Yeager; Gregg Magrane; Hidefumi Kinoshita; Nadine Nassif; Lorraine Meisner; Michael A. Newton; Frederic M. Waldman; Catherine A. Reznikoff

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Colonic Hamartoma Development by Anomalous Duplication in Cdx2Knockout Mice 1

Yoshitaka Tamai; Reiko Nakajima; Tomo-o Ishikawa; Kazuaki Takaku; Michael F. Seldin; Makoto M. Taketo

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Autocrine Interleukin-1β Production in Leukemia: Evidence for the Involvement of Mutated RAS6 1

Darrin M. Beaupre; Moshe Talpaz; Frank C. Marini, III; Richard J. Cristiano; Jack A. Roth; Zeev Estrov; Maher Albitar; Melvin H. Freedman; Razelle Kurzrock

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Carboxypeptidase A3 (CPA3): A Novel Gene Highly Induced by Histone Deacetylase Inhibitors during Differentiation of Prostate Epithelial Cancer Cells 1

Haojie Huang; Christopher P. Reed; Jin-San Zhang; Viji Shridhar; Liang Wang; David I. Smith

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Heparin/Heparan Sulfate Interacting Protein Gene Expression Is Up-regulated in Human Colorectal Carcinoma and Correlated with Differentiation Status and Metastasis 1

Yuxun Wang; Denis Cheong; Steven Chan; Shing Chuan Hooi

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Frameshift Mutations at Mononucleotide Repeats in caspase-5 and Other Target Genes in Endometrial and Gastrointestinal Cancer of the Microsatellite Mutator Phenotype 1

Simó Schwartz, Jr.; Hiroyuki Yamamoto; Manuel Navarro; Marisa Maestro; Jaume Reventós; Manuel Perucho

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Tumor Biology

Proteomics and Immunohistochemistry Define Some of the Steps Involved in the Squamous Differentiation of the Bladder Transitional Epithelium: A Novel Strategy for Identifying Metaplastic Lesions 1

Julio E. Celis; Pamela Celis; Morten Østergaard; Bodil Basse; Jette B. Lauridsen; Gitte Ratz; Hanne H. Rasmussen; Torben F. Ørntoft; Bente Hein; Hans Wolf; Ariana Celis

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The Viral Protein Apoptin Induces Apoptosis in UV-C-irradiated Cells from Individuals with Various Hereditary Cancer-prone Syndromes 1

Ying-Hui Zhang; Peter J. Abrahams; Alex J. van der Eb; Mathieu H. M. Noteborn

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Correction

C. Praml et al., Cancer Res., 58: 5014–5018, 1998

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