(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Micronuclei Formation with Chromosome Breaks and Gene Amplification Caused by Vpr, an Accessory Gene of Human Immunodeficiency Virus 1

Mari Shimura; Yuji Onozuka; Toshikazu Yamaguchi; Kiyohiko Hatake; Fumimaro Takaku; Yukihito Ishizaka

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Overexpression of H-Ryk in Mouse Fibroblasts Confers Transforming Ability in Vitro and in Vivo: Correlation with Up-Regulation in Epithelial Ovarian Cancer 1

Roy M. T. Katso; Sanjiv Manek; Simon Biddolph; Roger Whittaker; Mark F. L. Charnock; Mike Wells; Trivadi S. Ganesan

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A Novel Immunological Model for the Study of Prostate Cancer 1

Navesh Sharma; Jun Luo; Dawn A. Kirschmann; Yunxia O’Malley; Michael E. C. Robbins; Emmanuel T. Akporiaye; David M. Lubaroff; Paul M. Heidger; Mary J. C. Hendrix

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Helicobacter pylori Inhibits the G₁ to S Transition in AGS Gastric Epithelial Cells 1

Haim Shirin; Emilia Mia Sordillo; Sung H. Oh; Hirofumi Yamamoto; Thomas Delohery; I. Bernard Weinstein; Steven F. Moss

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Decay Accelerating Factor (CD55): A Target for Cancer Vaccines?1

Ian Spendlove; Li Li; James Carmichael; Lindy G. Durrant

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Major Histocompatibility Complex Class I Restricted Cytotoxic T Cells Specific for Natural Melanoma Peptides Recognize Unidentified Shared Melanoma Antigen(s)1

Maria Adele Imro; Simona Manici; Vincenzo Russo; Giuseppe Consogno; Matteo Bellone; Claudio Rugarli; Catia Traversari; Maria Pia Protti

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Methylation of CpGs as a Determinant of Transcriptional Activation at Alternative Promoters for Transforming Growth Factor-β3 1

William B. Archey; Matthew P. Sweet; Graham C. Alig; Bradley A. Arrick

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D-Type Cyclins Complex with the Androgen Receptor and Inhibit Its Transcriptional Transactivation Ability 1

Karen E. Knudsen; Webster K. Cavenee; Karen C. Arden

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CpG Island Hypermethylation in Human Colorectal Tumors Is Not Associated with DNA Methyltransferase Overexpression 1

Cindy A. Eads; Kathleen D. Danenberg; Kazuyuki Kawakami; Leonard B. Saltz; Peter V. Danenberg; Peter W. Laird

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Identification of Differentially Methylated Sequences in Colorectal Cancer by Methylated CpG Island Amplification 1

Minoru Toyota; Coty Ho; Nita Ahuja; Kam-Wing Jair; Qing Li; Mutsumi Ohe-Toyota; Stephen B. Baylin; Jean-Pierre J. Issa

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Identification of the TCL1/MTCP1-like 1 (TML1) Gene from the Region Next to the TCL1 Locus 1

Jun Sugimoto; Toyomasa Hatakeyama; Maria Grazia Narducci; Giandomenico Russo; Masaharu Isobe

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Adenovirus-mediated Gene Transfer of MMAC1/PTEN to Glioblastoma Cells Inhibits S Phase Entry by the Recruitment of p27^Kip1 into Cyclin E/CDK2 Complexes

I. Wayne Cheney; Saskia T. C. Neuteboom; Mei-Ting Vaillancourt; Muralidhara Ramachandra; Robert Bookstein

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Elevated Levels of Peritumoral Chondroitin Sulfate Are Predictive of Poor Prognosis in Patients Treated by Radical Prostatectomy for Early-Stage Prostate Cancer 1

Carmela Ricciardelli; David I. Quinn; Wendy A. Raymond; Kieran McCaul; Peter D. Sutherland; Phillip D. Stricker; John J. Grygiel; Robert L. Sutherland; Villis R. Marshall; Wayne D. Tilley; David J. Horsfall

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Methylation of the CD44 Metastasis Suppressor Gene in Human Prostate Cancer 1

Wei Lou; Diane Krill; Rajiv Dhir; Michael J. Becich; Jin-Tang Dong; Henry F. Frierson, Jr.; William B. Isaacs; John T. Isaacs; Allen C. Gao

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Association of Breast Cancer Progression with a Vitamin D Receptor Gene Polymorphism 1

Anna-Carin Lundin; Peter Söderkvist; Birgitta Eriksson; Malin Bergman-Jungeström; Sten Wingren; the South-East Sweden Breast Cancer Group

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Motility Inhibition and Apoptosis Are Induced by Metastasis-suppressing Gene Product CD82 and Its Analogue CD9, with Concurrent Glycosylation 1

Masaya Ono; Kazuko Handa; Donald A. Withers; Sen-itiroh Hakomori

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Carcinogenesis

Overexpression and Amplification of c-myc in the Syrian Hamster Kidney during Estrogen Carcinogenesis: A Probable Critical Role in Neoplastic Transformation 1

Jonathan J. Li; Xiaoying Hou; Sushanta K. Banerjee; De-Zhong Joshua Liao; Frederiki Maggouta; James S. Norris; Sara Antonia Li

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Inhibitory Effects of Caffeic Acid Phenethyl Ester on the Activity and Expression of Cyclooxygenase-2 in Human Oral Epithelial Cells and in a Rat Model of Inflammation 1

Pedro Michaluart; Jaime L. Masferrer; Adelaide M. Carothers; Kotha Subbaramaiah; Ben S. Zweifel; Carol Koboldt; Juan R. Mestre; Dezider Grunberger; Peter G. Sacks; Tadashi Tanabe; Andrew J. Dannenberg

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A Bile Acid-induced Apoptosis Assay for Colon Cancer Risk and Associated Quality Control Studies 1

Carol Bernstein; Harris Bernstein; Harinder Garewal; Pat Dinning; Rawah Jabi; Richard E. Sampliner; Margaret K. McCuskey; Madhulita Panda; Denise J. Roe; Lawrence L’Heureux; Claire Payne

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Differential Protection against Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA Damage in HepG2 Cells Stably Transfected with Allelic Variants of π Class Human Glutathione S-Transferase 1

Xun Hu; Christian Herzog; Piotr Zimniak; Shivendra V. Singh

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Clinical Investigations

Alterations of Intratumoral Pharmacokinetics of 5-Fluorouracil in Head and Neck Carcinoma during Simultaneous Radiochemotherapy 1

Heinz-Peter Schlemmer; Markus Becker; Peter Bachert; Andreas Dietz; Volker Rudat; Bernhard Vanselow; Petra Wollensack; Iwan Zuna; Michael V. Knopp; Hagen Weidauer; Michael Wannenmacher; Gerhard van Kaick

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Endocrinology

Insulin-like Growth Factor Binding Protein-related Protein 1 (IGFBP-rP1) Is a Potential Tumor Suppressor Protein for Prostate Cancer 1

Cynthia C. Sprenger; Susan E. Damon; Vivian Hwa; Ron G. Rosenfeld; Stephen R. Plymate

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Experimental Therapeutics

A Novel Animal Model for Hemangiomas: Inhibition of Hemangioma Development by the Angiogenesis Inhibitor TNP-470 1

Sandra Liekens; Erik Verbeken; Michel Vandeputte; Erik De Clercq; Johan Neyts

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Vesicular Stomatitis Virus G Pseudotyped Retrovector Mediates Effective in Vivo Suicide Gene Delivery in Experimental Brain Cancer 1

Jacques Galipeau; Hewei Li; André Paquin; Franca Sicilia; George Karpati; Josephine Nalbantoglu

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Sustained in Vivo Regression of Dunning H Rat Prostate Cancers Treated with Combinations of Androgen Ablation and Trk Tyrosine Kinase Inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)1

Daniel J. George; Craig A. Dionne; Jitesh Jani; Thelma Angeles; Chikara Murakata; John Lamb; John T. Isaacs

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O⁶-Benzylguanine: A Clinical Trial Establishing the Biochemical Modulatory Dose in Tumor Tissue for Alkyltransferase-directed DNA Repair 1

Timothy P. Spiro; Stanton L. Gerson; Lili Liu; Susan Majka; John Haaga; Charles L. Hoppel; Stephen T. Ingalls; James M. Pluda; James K. V. Willson

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A New in Vivo Method to Study P-Glycoprotein Transport in Tumors and the Blood-Brain Barrier 1

N. Harry Hendrikse; Elisabeth G. E. de Vries; Lizette Eriks-Fluks; Winette T. A. van der Graaf; Geke A. P. Hospers; Antoon T. M. Willemsen; Willem Vaalburg; Eric J. F. Franssen

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Purine Analogue 6-Methylmercaptopurine Riboside Inhibits Early and Late Phases of the Angiogenesis Process 1

Marco Presta; Marco Rusnati; Mirella Belleri; Lucia Morbidelli; Marina Ziche; Domenico Ribatti

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Cisplatin Inhibits Paclitaxel-induced Apoptosis in Cisplatin-resistant Ovarian Cancer Cell Lines: Possible Explanation for Failure ofCombination Therapy 1

Patricia L. Judson; Joanna M. Watson; Paola A. Gehrig; Wesley C. Fowler, Jr.; J. Stephen Haskill

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Immunology

Protein Transfer of Glycosyl-phosphatidylinositol-B7-1 into Tumor Cell Membranes: A Novel Approach to Tumor Immunotherapy 1

Rebecca S. McHugh; Shanmugam Nagarajan; Yi-Chong Wang; Kenneth W. Sell; Periasamy Selvaraj

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Molecular Biology and Genetics

Elevated Frequency of Loss of Heterozygosity in Mammary Tumors Arising in Mouse Mammary Tumor Virus/neu Transgenic Mice 1

Marc Cool; Paul Jolicoeur

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Activated Ki-Ras Suppresses 12-O-Tetradecanoylphorbol-13-acetate-induced Activation of the c-Jun NH₂-Terminal Kinase Pathway in Human Colon Cancer Cells 1

Koji Okumura; Senji Shirasawa; Miharu Nishioka; Takehiko Sasazuki

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Resistance to Apoptosis in CTLL-2 Cells Overexpressing B-Myb Is Associated with B-Myb-dependent bcl-2 Induction 1

Emanuela Grassilli; Paolo Salomoni; Danilo Perrotti; Claudio Franceschi; Bruno Calabretta

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Alkyl-Lysophospholipids Activate the SAPK/JNK Pathway and Enhance Radiation-induced Apoptosis 1

Gerald A. Ruiter; Shuraila F. Zerp; Harry Bartelink; Wim J. van Blitterswijk; Marcel Verheij

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Loss of the ARF Tumor Suppressor Reverses Premature Replicative Arrest but not Radiation Hypersensitivity Arising from Disabled Atm Function 1

Takehiko Kamijo; Esther van de Kamp; Miriam J. Chong; Frederique Zindy; J. Alan Diehl; Charles J. Sherr; Peter J. McKinnon

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Tumor Biology

Overexpression of Cyclins D1 and E Is Frequent in Bronchial Preneoplasia and Precedes Squamous Cell Carcinoma Development 1

Fulvio Lonardo; Valerie Rusch; John Langenfeld; Ethan Dmitrovsky; David S. Klimstra

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Expression and Up-Regulation of Retinoic Acid Receptor-β Is Associated with Retinoid Sensitivity and Colony Formation in Esophageal Cancer Cell Lines 1

Xiao-Chun Xu; Xiaoming Liu; Eiichi Tahara; Scott M. Lippman; Reuben Lotan

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HMGI(Y) and HMGI-C Genes Are Expressed in Neuroblastoma Cell Lines and Tumors and Affect Retinoic Acid Responsiveness 1

Giuseppe Giannini; Lucia Di Marcotullio; Elisabetta Ristori; Massimo Zani; Marco Crescenzi; Susanna Scarpa; Giulia Piaggio; Alessandra Vacca; Fiorenzo A. Peverali; Francesca Diana; Isabella Screpanti; Luigi Frati; Alberto Gulino

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Mediation of N-(4-Hydoxyphenyl)retinamide-induced Apoptosis in Human Cancer Cells by Different Mechanisms 1

Shi-Yong Sun; Wanbo Li; Ping Yue; Scott M. Lippman; Waun K. Hong; Reuben Lotan

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Relationship between Hyaluronan Production and Metastatic Potential of Mouse Mammary Carcinoma Cells 1

Naoki Itano; Takahiro Sawai; Osamu Miyaishi; Koji Kimata

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