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Volume 43, Issue 8

1 August 1983

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Front Matter
Table of Contents
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Editorial Board

ISSN 0008-5472

EISSN 1538-7445

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Articles

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Articles

Perspectives in Cancer Research

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Biochemical Strategy of Cancer Cells and the Design of Chemotherapy: G. H. A. Clowes Memorial Lecture ¹

George Weber

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Inhibition of DNA Methylation in L1210 Leukemic Cells by 5-Aza-2′-deoxycytidine as a Possible Mechanism of Chemotherapeutic Action ¹

Vincent L. Wilson; Peter A. Jones; Richard L. Momparler

Abstract

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Ketone Body, Glucose, Lactic Acid, and Amino Acid Utilization by Tumors in Vivo in Fasted Rats ¹

Leonard A. Sauer; Robert T. Dauchy

Abstract

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Toxicity of Methyldopa (Aldomet) to Mouse Neuroblastoma Cells in Vivo¹

Ewa Chelmicka-Schorr; Michael G. Sportiello; Gillis R. Otten; Barry G. W. Arnason

Abstract

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Demonstration of Immunogenicity with the Poorly Immunogenic B16 Melanoma ¹

Cihanghir Celik; David A. Lewis; Martin H. Goldrosen

Abstract

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Comparison of the Sister Chromatid Exchange and Cell Survival Assays as a Measure of Tumor Cell Sensitivity in Vitro to cis-Diamminedichloroplatinum (II)¹

Philip J. Tofilon; Mary E. Williams; Mary Helen Barcellos; Dennis F. Deen

Abstract

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Kinetics of Adenosine 3′:5′-Monophosphate-dependent Protein Kinase Activation and Inhibition of Thymidine Incorporation into DNA in P1798 Lymphosarcoma Cells ¹

Carolyn A. Michnoff; Becky A. de la Houssaye; Ruthann A. Masaracchia

Abstract

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Effects of Extreme Hypoxia on the Growth and Viability of EMT6/SF Mouse Tumor Cells in Vitro¹

Dennis C. Shrieve; Dennis F. Deen; John W. Harris

Abstract

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Relationship of Adriamycin Concentrations to the DNA Lesions Induced in Hypoxic and Euoxic L1210 Cells ¹

Milan Potmesil; Stanley Kirschenbaum; Mervyn Israel; Mark Levin; Vinod K. Khetarpal; Robert Silber

Abstract

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Reduction of Estrogen Receptor Concentration in MCF-7 Human Breast Carcinoma Cells following Exposure to Chemotherapeutic Drugs ¹

Kuo-Pao Yang; Naguib A. Samaan

Abstract

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Time-Dose Relationships for Simultaneous Misonidazole and 1,3-Bis(2-chloroethyl)-1-nitrosourea Exposures in Vitro¹

R. Timothy Mulcahy; Nancy Dembs

Abstract

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Mutagenicity and Cytotoxicity of Five Antitumor Ellipticines in Mammalian Cells and Their Structure-Activity Relationships in Salmonella¹

David M. DeMarini; Suzy Cros; Claude Paoletti; Pierre Lecointe; Abraham W. Hsie

Abstract

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In Vitro Sensitivity to Steroid Hormones and Cytotoxic Agents of Normal and Malignant Lymphocyte Colony-forming Cells ¹

Raymond Taetle; Dong To; John Mendelsohn

Abstract

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Effect of the Prostaglandin Synthetase Inhibitor Indomethacin on 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis in Rats Fed Different Levels of Fat ¹

Christopher A. Carter; Richard J. Milholland; Wendy Shea; Margot M. Ip

Abstract

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Specific Binding of [³H]Phorbol Dibutyrate to Phorbol Diesterresponsive and -resistant Clones of a Human Myeloid Leukemia (KG-1) Line 1

Robert I. Lehrer; Lenore E. Cohen; H. Phillip Koeffler

Abstract

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Biological Effects and Structure-Activity Relationships of 1,2-Dihydropyrido[3,4-b]pyrazines ¹

Glynn P. Wheeler; Bonnie J. Bowdon; Caroll Temple, Jr.; Doris J. Adamson; Joliet Webster

Abstract

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Differential Potentiation of 1,3-Bis(2-chloroethyl)-1-nitrosourea by α-Difluoromethylornithine in Chloroethylnitrosourea-sensitive and -resistant 9L Rat Brain Tumor Cells in Vitro¹

Stina M. Oredsson; Philip J. Tofilon; Burt G. Feuerstein; Dennis F. Deen; Mark L. Rosenblum; Laurence J. Marton

Abstract

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Metabolic Activation of Styrene by Erythrocytes Detected as Increased Sister Chromatid Exchanges in Cultured Human Lymphocytes ¹

Hannu Norppa; Harri Vainio; Marja Sorsa

Abstract

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Effects of Tamoxifen on Human Breast Cancer Cell Cycle Kinetics: Accumulation of Cells in Early G₁ Phase ¹

C. Kent Osborne; David H. Boldt; Gary M. Clark; Jeffrey M. Trent

Abstract

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Double Determinant Immunoassay to Measure a Human High-molecular-weight Melanoma-associated Antigen ¹

Patrizio Giacomini; Ah Kau Ng; Raphe R. S. Kantor; Pier Giorgio Natali; Soldano Ferrone

Abstract

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Effects of Vincristine on Cell Survival, Cell Cycle Progression, and Mitotic Accumulation in Asynchronously Growing Sarcoma 180 Cells

Hamza Mujagic; Shan-Shan Chen; Richard Geist; Sandra J. Occhipinti; Bruce M. Conger; Charles A. Smith; William H. Schuette; Stanley E. Shackney

Abstract

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Schedule Dependence of Vincristine Lethality in Sarcoma 180 Cells following Partial Synchronization with Hydroxyurea

Hamza Mujagic; Bruce M. Conger; Charles A. Smith; Sandra J. Occhipinti; William H. Schuette; Stanley E. Shackney

Abstract

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Immunochemical Study on the Contributions of Two Molecular Species of Microsomal Cytochrome P-450 to the Metabolism of Benzo(a)pyrene by Rat Liver Microsomes ¹

Eiichi Hara; Kaname Kawajiri; Yusaku Tagashira

Abstract

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Quenching of DNA:Platinum(II) Monoadducts as a Possible Mechanism of Resistance to cis-Diamminedichloroplatinum(II) in L1210 Cells

Kenneth Micetich; Leonard A. Zwelling; Kurt W. Kohn

Abstract

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Rapid and Reversible Inhibition of Junctional Communication by Tumor Promoters in a Mouse Cell Line ¹

D. James Fitzgerald; Spencer E. Knowles; F. John Ballard; Andrew W. Murray

Abstract

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Distribution, Metabolism, and Excretion of 1-(2-Fluoro-2-deoxy-β-d-arabinofuranosyl)thymine and 1-(2-Fluoro-2-deoxy-β-d-arabinofuranosyl)-5-iodocytosine ¹

Frederick S. Philips; Aaron Feinberg; Ting-Chao Chou; Pedro M. Vidal; Tsann-Long Su; Kyoichi A. Watanabe; Jack J. Fox

Abstract

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Enhanced Macromolecular Binding of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]-formamide in Germfree versus Conventional Rats ¹

Kenneth C. Morton; Ching Y. Wang

Abstract

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Effect of Pyran Copolymer on Activation of Murine Macrophages: Evidence for Incomplete Activation by Use of Functional Markers ¹

Dolph O. Adams; William J. Johnson; Phillip A. Marino; Jack H. Dean

Abstract

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Presence of Specific Binding Sites for Phorbol Ester Tumor Promoters in Human Epidermal and Dermal Cells in Culture but Lack of Down Regulation in Epidermal Cells ¹

Kazuhiro Chida; Toshio Kuroki

Abstract

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Genetic Differences in Metabolism of Benzo(a)pyrene in Cultured Epidermal and Dermal Cells of Responsive and Nonresponsive Mice ¹

Jiro Hosomi; Nobuo Nemoto; Toshio Kuroki

Abstract

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Energy Metabolism in Nongrowing Mice with Sarcoma ¹

Lars Lindmark; Staffan Edström; Lars Ekman; Ingvar Karlberg; Kent Lundholm

Abstract

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Inhibition of Human Lymphoma DNA-dependent RNA Polymerase Activity by 6-Mercaptopurine Ribonucleoside Triphosphate ¹

Russell T. Kawahata; Linda F. Chuang; Charles A. Holmberg; Bennie I. Osburn; Ronald Y. Chuang

Abstract

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Cytochrome P-450-dependent Xenobiotic Metabolizing Activity in Zymbal's Gland, a Specialized Sebaceous Gland of Rodents

Roberta J. Pohl; James R. Fouts

Abstract

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Genetic Control of Susceptibility of Rats to Gastric Carcinoma ¹

Hiroko Ohgaki; Takashi Kawachi; Norio Matsukura; Kazuhide Morino; Moriyoshi Miyamoto; Takashi Sugimura

Abstract

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Production of Growth-inhibitory Activity in Serum-free Medium by Human Monocytic Leukemia Cells ¹

Edwin V. Gaffney; Shiow-Chuan Tsai; Marie L. Dell'Aquila; Susan E. Lingenfelter

Abstract

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Effect of Dietary Protein Concentration on Yield of Mutagenic Metabolites from 1,2-Dimethylhydrazine in Mice ¹

Frank W. Kari; James B. Johnston; C. Richard Truex; Willard J. Visek

Abstract

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Differential Response of an Ovarian-responsive Mouse Mammary Tumor to Androgenic and Estrogenic Agents ¹

Akio Matsuzawa; Yukiko Ikeda

Abstract

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Effect of the Preestrogen 4-Androstene-3,17-dion-19-al on the Dunning R3327 Prostatic Adenocarcinoma

Thomas A. Marks; Vladimir Petrow

Abstract

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Inability of Cytoplasmic or Nuclear Androgen Receptor Content or Distribution to Distinguish Benign from Carcinomatous Human Prostate ¹

Sydney A. Shain; Lester S. Gorelic; Robert W. Klipper; Ibrahim Ramzy; Donald E. Novicki; Howard M. Radwin; Donald L. Lamm

Abstract

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Enhancement of Sensitivity to Adriamycin in Resistant P388 Leukemia by the Calmodulin Inhibitor Trifluoperazine ¹

Ram Ganapathi; Dale Grabowski

Abstract

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Likelihood of the New Antitumoral Drug 10-[γ-Diethylaminopropylamino]-6-methyl-5H-pyrido[3′,4′:4,5]pyrrolo[2,3-g]isoquinoline (BD-40), a Pyridopyrroloisoquinoline Derivative, to Induce DNA Strand Breaks in Vivo and Its Nonmutagenicity in Yeast ¹

E. Moustacchi; V. Favaudon; E. Bisagni

Abstract

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Role of Whole-Body Lipids and Nitrogen as Limiting Factors for Survival in Tumor-bearing Mice with Anorexia and Cachexia ¹

Elisabeth Edén; Lars Lindmark; Ingvar Karlberg; Kent Lundholm

Abstract

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Dose-Response Relationships for the Binding of Benzo(a)pyrene Metabolites to DNA and Protein in Lung, Liver, and Forestomach of Control and Butylated Hydroxyanisole-treated Mice

Peter I. Adriaenssens; Catherine M. White; Marshall W. Anderson

Abstract

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Kinetics of N- and C-Hydroxylations of 2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver Microsomes: Implications for Carcinogenesis

Michael E. McManus; Rodney F. Minchin; Nancy Sanderson; Peter J. Wirth; Snorri S. Thorgeirsson

Abstract

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Flow Cytometric and Morphological Studies of Ovarian Carcinoma Cell Lines and Xenografts

Caroline van Haaften-Day; Peter Russell; Cathy Rugg; Edward J. Wills; Martin H. N. Tattersall

Abstract

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Inhibition of Mouse Skin Tumor Promotion and of Promoter-stimulated Epidermal Polyamine Biosynthesis by α-Difluoromethylornithine ¹

Masaharu Takigawa; Ajit K. Verma; R. C. Simsiman; R. K. Boutwell

Abstract

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Detection and Measurement of α-Fetoprotein in Human Breast Cancer Cytosol after Treatment with 0.4 m Potassium Chloride

Edward J. Sarcione; Martin Zloty; Daniel S. Delluomo; Gerald Mizejewski; Herbert Jacobson

Abstract

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Subcellular Distribution of Inorganic Pyrophosphatase Activity in Various Normal and Neoplastic Cell Types ¹

Jennie B. Shatton; Albert Williams; Sidney Weinhouse

Abstract

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Enhanced Synthesis of a Specific Protein by 12-O-Tetradecanoylphorbol-13-acetate in Cultured Chick Embryo Muscle Cells

Bianca M. Zani; Mario Molinaro

Abstract

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Comparable Growth Regulation of Five Human Tumor Cell Lines by Neonatal Human Lung Fibroblasts in Semisolid Culture Media ¹

David Kirk; Susumu Kagawa; Gudrun Vener

Abstract

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cis-Diamminedichloroplatinum(II) Nephrotoxicity: Tubular Function after Rescue with Sodium Diethyldithiocarbamate in Rats

W. C. Elliott; Samuel R. Newcom; Donald C. Houghton; Joan Baines-Hunter; W. M. Bennett

Abstract

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Characteristics of a Calcitonin-responsive Cell Line Derived from a Human Osteosarcoma ¹

Gabriel Eilon; Janice Perkins; Michael V. Viola

Abstract

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Indirect Immunofluorescence Studies of Proliferating Cell Nuclear Antigen in Nucleoli of Human Tumor and Normal Tissues ¹

Pui-Kwong Chan; Rebecca Frakes; Eng M. Tan; Michael G. Brattain; Karel Smetana; Harris Busch

Abstract

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Characterization of Protein Phosphorylation of the Cytosol of AH-66 Hepatoma Ascites Cells ¹

Kazuyasu Nakaya; Takashi Shimizu; Yoshihide Segawa; Shigeo Nakajo; Yasuharu Nakamura

Abstract

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Aneuploidy Induction and Cell Transformation by Diethylstilbestrol: A Possible Chromosomal Mechanism in Carcinogenesis

Takeki Tsutsui; Heiji Maizumi; John A. McLachlan; J. Carl Barrett

Abstract

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Reconfirmation of Indirect Induction of Radiogenic Lymphomas Using Thymectomized, Irradiated B10 Mice Grafted with Neonatal Thymuses from Thy 1 Congenic Donors ¹

Masahiro Muto; Toshihiko Sado; Isamu Hayata; Fumio Nagasawa; Hitoko Kamisaku; Eiko Kubo

Abstract

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Characterization of Two Metastatic Subpopulations Originating from a Single Human Colon Carcinoma ^1,2

Ellen N. Spremulli; Caron Scott; Debora E. Campbell; N. Peter Libbey; Dan Shochat; David V. Gold; Daniel L. Dexter

Abstract

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Dimorphism of Sister Chromatid Exchange in Bloom's Syndrome B- and T-Cell Lines Transformed with Epstein-Barr and Adult T-Cell Leukemia Viruses ¹

Yukimasa Shiraishi; Shizuo Yoshimoto; Isao Miyoshi; Naomi Kondo; Tadao Orii; Avery A. Sandberg

Abstract

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Glycoprotein Exhibiting Immunological and Enzymatic Activities of Human Prostatic Acid Phosphatase ¹

Ming-Fong Lin; Ching-li Lee; Farida S. Sharief; Steven S-L. Li; T. Ming Chu

Abstract

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Glucocorticoid Receptor Levels in Mouse Skin after Repetitive Applications of 12-O-Tetradecanoylphorbol-13-acetate and Mezerein ¹

Kowetha A. Davidson; Thomas J. Slaga

Abstract

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Unilateral Chromatid Damage: A New Basis for 6-Thioguanine Cytotoxicity1 ¹

Jonathan Maybaum; H. George Mandel

Abstract

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Monoclonal Antibodies to Carcinoembryonic Antigen: Ionic Strength as a Factor in the Selection of Antibodies for Immunoscintigraphy ¹

Charles M. Haskell; Franz Buchegger; Magali Schreyer; Stefan Carrel; Jean-Pierre Mach

Abstract

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Glucocorticoid-resistant Human Acute Lymphoblastic Leukemic Cell Line with Functional Receptor ¹

Robert Zawydiwski; Jeffrey M. Harmon; E. Brad Thompson

Abstract

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Characterization of a Family of Glycoproteins Associated with the Bile Canalicular Membrane of Normal Hepatocytes but Not Expressed by Two Transplantable Rat Hepatocellular Carcinomas ¹

Douglas C. Hixson; James P. Allison; Judith E. Chesner; Marilyn J. Leger; Linda L. Ridge; Earl F. Walborg, Jr.

Abstract

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Immunohistological Study of Precancerous Mucus Modification in Human Distal Colonic Polyps ¹

J. Bara; O. Languille; M. C. Gendron; N. Daher; E. Martin; P. Burtin

Abstract

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Association of the Human Type C Retrovirus with a Subset of Adult T-Cell Cancers

Robert C. Gallo; V. S. Kalyanaraman; M. G. Samgadharan; Ann Sliski; Eric C. Vonderheid; M. Maeda; Yoshinobu Nakao; Kazumasa Yamada; Yohei Ito; Nancy Gutensohn; Sharon Murphy; Paul A. Bunn, Jr.; Daniel Catovsky; M. F. Greaves; Douglas W. Blayney; William Blattner; W. F. H. Jarrett; Harald zur Hausen; M. Seligmann; J. C. Brouet; Barton F. Haynes; Brian V. Jegasothy; Elaine Jaffe; Jeffrey Cossman; Samuel Broder; Richard I. Fisher; David W. Golde; Marjorie Robert-Guroff

Abstract

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Epidemiology of Coffee and Pancreatic Cancer ¹

E. L. Wynder; N. E. L. Hall; M. Polansky

Abstract

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Phase I Evaluation and Pharmacokinetics of Aziridinylbenzoquinone Using a Weekly Intravenous Schedule ¹

Rudolf B. Schilcher; John D. Young; Lawrence P. Leichman; Charles D. Haas; Laurence H. Baker

Abstract

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Transcription of Hematopoietic-associated Oncogenes in Childhood Leukemia ¹

Dan Rosson; Allan Tereba

Abstract

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Mitoxantrone in Patients with Acute Leukemia in Relapse ¹

Paolo Alberto Paciucci; Takao Ohnuma; Janet Cuttner; Richard T. Silver; James F. Holland

Abstract

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Deficiency in Epstein-Barr Virus Receptors on B-Lymphocytes of Preleukemia Patients ¹

David J. Volsky; Ronald W. Anderson

Abstract

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Effects of S-Phase-specific Agents on Granulocyte-Macrophage and Erythroid Progenitor Cells Obtained from Normal Individuals and from Patients with Chronic Myelogenous Leukemia ¹

Kazuo Kubota; Harvey D. Preisler; Catherine Costanzo

Abstract

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Production and Molecular Size Heterogeneity of Immunoreactive Gastrinreleasing Peptide in Fetal and Adult Lungs and Primary Lung Tumors ¹

Ken Yamaguchi; Kaoru Abe; Toru Kameya; Isamu Adachi; Sanae Taguchi; Kotomi Otsubo; Noboru Yanaihara

Abstract

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Plasma Levels of Estrone, Estrone Sulfate, and Estradiol and the Percentage of Unbound Estradiol in Postmenopausal Women with and without Breast Disease ¹

M. J. Reed; R. W. Cheng; C. T. Noel; H. A. F. Dudley; V. H. T. James

Abstract

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Circadian Rhythmicity of Polyamine Urinary Excretion ¹

William J. M. Hrushesky; James Merdink; Mahmoud M. Abdel-Monem

Abstract

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Tamoxifen-induced Fluorescence as a Marker of Human Breast Tumor Cell Responsiveness to Hormonal Manipulations: Correlation with Progesterone Receptor Content and Ultrastructural Alterations ¹

Jacqueline Mouriquand; Michèle Jacrot; Josette Louis; Marie-Ange Mermet; Simone Saez; Jean-Clément Sage; Claude Mouriquand

Abstract

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High-Affinity Erythrocyte Rosette Formation and Inhibition in Premalignant Disease of the Uterine Cervix

John Bashford; Ian R. Gough

Abstract

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Depression of High-Affinity Rosette Formation in Dysplasia and Carcinoma in Situ of the Uterine Cervix: Mediation by Serum Factors

John Bashford; Ian R. Gough

Abstract

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Occurrence of Fibrin and Tissue Factor Antigen in Human Small Cell Carcinoma of the Lung ¹

Leo R. Zacharski; Alan R. Schned; George D. Sorenson

Abstract

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The Governance of Science at the National Cancer Institute: A Perspective on Misperceptions ¹

Vincent T. DeVita, Jr.

Abstract

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Multidisciplinary Approach to Management of Patients with Mesothelioma ¹

Nikolay V. Dimitrov, M.D.; Samuel M. McMahon, M.D.; David T. Carr, M.D.

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Announcements

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Mutagenicity of Diol-Epoxides and Tetrahydroepoxides of Benz(a)acridine and Benz(c)acridine in Bacteria and in Mammalian Cells

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Growth of Mammalian Multicellular Tumor Spheroids

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Recent Deaths

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