Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

Cancer Res (2007) 67 (16): 7825–7832.
This article has been cited by the following articles in journals that are participating in CrossRef Cited-by Linking.
Acrolein Increases the Pulmonary Tumorigenic Activity of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
  • Lisa A. Peterson
  • Donna Seabloom
  • William E. Smith
  • Karin R. Vevang
  • Davis M. Seelig
  • Lin Zhang
  • Timothy S. Wiedmann
Chemical Research in Toxicology (2022) 35 (10): 1831.
Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung
  • Nataliia Kovalchuk
  • Joseph L. Jilek
  • Laura S. Van Winkle
  • Nathan J. Cherrington
  • Xinxin Ding
Antioxidants (2022) 11 (2): 219.
Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung
  • Lisa A. Peterson
  • Marissa K. Oram
  • Monica Flavin
  • Donna Seabloom
  • William E. Smith
  • M. Gerard O’Sullivan
  • Karin R. Vevang
  • Pramod Upadhyaya
  • Alessia Stornetta
  • Andrew C. Floeder
  • Yen-Yi Ho
  • Lin Zhang
  • Stephen S. Hecht
  • Silvia Balbo
  • Timothy S. Wiedmann
Chemical Research in Toxicology (2021) 34 (3): 723.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation
  • Mariko Shikata
  • Tatsushi Toyooka
  • Yukako Komaki
  • Yuko Ibuki
Chemical Research in Toxicology (2021) 34 (12): 2512.
Prenatal stress enhances NNK-induced lung tumors in A/J mice
  • Tomoaki Ito
  • Harumi Saeki
  • Xin Guo
  • Polina Sysa-Shah
  • Jonathan Coulter
  • Kellie L K Tamashiro
  • Richard S Lee
  • Hajime Orita
  • Koichi Sato
  • Shun Ishiyama
  • Alicia Hulbert
  • William E Smith
  • Lisa A Peterson
  • Malcolm V Brock
  • Kathleen L Gabrielson
Carcinogenesis (2020) 41 (12): 1713.
Antioxidative and antimutagenic effects of Panicum miliaceum L.
  • Jeong Seob Park
  • Jong Soon Lee
  • Jeong Ho Lee
Korean Journal of Food Preservation (2020) 27 (2): 261.
Identification of dynamic signatures associated with smoking‐related squamous cell lung cancer and chronic obstructive pulmonary disease
  • Xiaoru Sun
  • Jingzhe Shang
  • Aiping Wu
  • Jingyan Xia
  • Feng Xu
Journal of Cellular and Molecular Medicine (2020) 24 (2): 1614.
The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs
  • Yuan Gao
  • Sharon Miksys
  • Roberta M. Palmour
  • Rachel F. Tyndale
Molecular Pharmacology (2020) 98 (6): 658.
Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung
  • Nataliia Kovalchuk
  • Qing-Yu Zhang
  • Laura Van Winkle
  • Xinxin Ding
Toxicological Sciences (2020) 177 (2): 334.
DFT and MD Studies of Formaldehyde-Derived DNA Adducts: Molecular-Level Insights into the Differential Mispairing Potentials of the Adenine, Cytosine, and Guanine Lesions
  • Katie A. Wilson
  • Josh L. Garden
  • Natasha T. Wetmore
  • Lindey R. Felske
  • Stacey D. Wetmore
The Journal of Physical Chemistry A (2019) 123 (29): 6229.
Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
  • F. Oesch
  • E. Fabian
  • Robert Landsiedel
Archives of Toxicology (2019) 93 (12): 3419.
Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
  • Qin Qin
  • Qiangen Wu
  • Yiying Wang
  • Rui Xiong
  • Lei Guo
  • Xin Fu
  • Hans Rosenfeldt
  • Matthew Bryant
  • Xuefei Cao
Toxicology in Vitro (2019) 55: 185.
Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress
  • Debin Zheng
  • Yumiao Chen
  • Sifan Ai
  • Renshu Zhang
  • Zhengfeng Gao
  • Chunhui Liang
  • Li Cao
  • Yaoxia Chen
  • Zhangyong Hong
  • Yang Shi
  • Ling Wang
  • Xingyi Li
  • Zhimou Yang
Research (2019) 2019
The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
  • Lindsay Reed
  • Volker M Arlt
  • David H Phillips
Carcinogenesis (2018) 39 (7): 851.
Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK
  • Lisa A. Peterson
Chemical Research in Toxicology (2017) 30 (1): 420.
CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers
  • Masaki Kumondai
  • Hiroki Hosono
  • Kazuhiko Orikasa
  • Yoichi Arai
  • Tomio Arai
  • Haruhiko Sugimura
  • Seiichiro Ozono
  • Takayuki Sugiyama
  • Tatsuya Takayama
  • Takamitsu Sasaki
  • Noriyasu Hirasawa
  • Masahiro Hiratsuka
Biological & Pharmaceutical Bulletin (2016) 39 (10): 1683.
Comparative DNA adduct formation and induction of colonic aberrant crypt foci in mice exposed to 2-amino-9H-pyrido[2,3-b]indole, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, and azoxymethane
  • Sangyub Kim
  • Jingshu Guo
  • M. Gerald O'Sullivan
  • Daniel D. Gallaher
  • Robert J. Turesky
Environmental and Molecular Mutagenesis (2016) 57 (2): 125.
Multiclass Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultraperformance Liquid Chromatography–Tandem Mass Spectrometry
  • Jingshu Guo
  • Byeong Hwa Yun
  • Pramod Upadhyaya
  • Lihua Yao
  • Sesha Krishnamachari
  • Thomas A. Rosenquist
  • Arthur P. Grollman
  • Robert J. Turesky
Analytical Chemistry (2016) 88 (9): 4780.
The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
  • Volker M. Arlt
  • Colin J. Henderson
  • C. Roland Wolf
  • Marie Stiborová
  • David H. Phillips
Toxicology Research (2015) 4 (3): 548.
A Comparative Study of Physiological Activity and Ingredient Analysis of Glycyrrhiza uralensis Fischer Stems and Leaves Cultivated with Different Wavelength of LED Lights
  • Keuk Soo Bang
  • Young Nam Chang
  • Jong Sik Jin
  • Sang A Park
  • Jae Soo Lim
  • Jeong Sub Park
  • Jong Sung Kim
  • Jeong Ho Lee
Korean Journal of Plant Resources (2015) 28 (1): 126.
γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • Yuko Ibuki
  • Mariko Shikata
  • Tatsushi Toyooka
Toxicology in Vitro (2015) 29 (7): 1831.
ABSTRACTS FROM THE 10THINTERNATIONAL ISSX MEETING
Drug Metabolism Reviews (2014) 45 (sup1): 1.
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse
  • Lei Li
  • Vandana Megaraj
  • Yuan Wei
  • Xinxin Ding
Carcinogenesis (2014) 35 (11): 2584.
Tetracycline-Regulated Mouse Models of Cancer
  • Elizabeth S. Yeh
  • Ann Vernon-Grey
  • Heather Martin
  • Lewis A. Chodosh
Cold Spring Harbor Protocols (2014) 2014 (10): pdb.top069823.
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice
  • Vandana Megaraj
  • Xinxin Ding
  • Cheng Fang
  • Nataliia Kovalchuk
  • Yi Zhu
  • Qing-Yu Zhang
Chemical Research in Toxicology (2014) 27 (4): 656.
Generation and Characterization of a Novel CYP2A13-Transgenic Mouse Model
  • Kunzhi Jia
  • Lei Li
  • Zhihua Liu
  • Matthew Hartog
  • Kerri Kluetzman
  • Qing-Yu Zhang
  • Xinxin Ding
Drug Metabolism and Disposition (2014) 42 (8): 1341.
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone:in vivostudies using a CYP2A13-humanized mouse model
  • Vandana Megaraj
  • Xin Zhou
  • Fang Xie
  • Zhihua Liu
  • Weizhu Yang
  • Xinxin Ding
Carcinogenesis (2014) 35 (1): 131.
NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology
  • David S. Riddick
  • Xinxin Ding
  • C. Roland Wolf
  • Todd D. Porter
  • Amit V. Pandey
  • Qing-Yu Zhang
  • Jun Gu
  • Robert D. Finn
  • Sebastien Ronseaux
  • Lesley A. McLaughlin
  • Colin J. Henderson
  • Ling Zou
  • Christa E. Flück
Drug Metabolism and Disposition (2013) 41 (1): 12.
Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users
  • Linda C. Blake
  • Anuradha Roy
  • David Neul
  • Frank J. Schoenen
  • Jeffrey Aubé
  • Emily E. Scott
Pharmaceutical Research (2013) 30 (9): 2290.
A Comparative Study of Physiological Activity of Glycyrrhiza uralensis Fischer Stems and Leaves by Processing Methods
  • Jeong Seob Park
  • Sun Hee Park
  • Il Soo Oh
  • Young Nam Chang
  • Keuk Soo Bang
  • Eun Ju Byeon
  • Jeong Ho Lee
Korean Journal of Plant Resources (2013) 26 (5): 539.
The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: Utility of renal specific P450 reductase knockout mouse models
  • Senyan Liu
  • Yunyi Yao
  • Shijun Lu
  • Kenneth Aldous
  • Xinxin Ding
  • Changlin Mei
  • Jun Gu
Toxicology and Applied Pharmacology (2013) 272 (1): 230.
Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development
  • Satya P. Panda
  • Anyonya R. Guntur
  • Srikanth R. Polusani
  • Roberto J. Fajardo
  • Peter T. Gakunga
  • Linda J. Roman
  • Bettie Sue Masters
  • Christoph Winkler
PLoS ONE (2013) 8 (9): e75638.
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis
  • Catherine Wassenaar
  • Qiong Dong
  • Christopher Amos
  • Margaret Spitz
  • Rachel Tyndale
International Journal of Molecular Sciences (2013) 14 (4): 8381.
Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model
  • Yuan Wei
  • Lei Li
  • Xin Zhou
  • Qing-Yu Zhang
  • Anwar Dunbar
  • Fang Liu
  • Kerri Kluetzman
  • Weizhu Yang
  • Xinxin Ding
Drug Metabolism and Disposition (2013) 41 (1): 132.
Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model
  • C. Fang
  • V.J. Bolivar
  • J. Gu
  • W. Yang
  • S.O. Zeitlin
  • X. Ding
Neuroscience (2012) 218: 170.
Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells
  • Xue-Jiao Yang
  • Hui-Yuan Lu
  • Zi-Yin Li
  • Qian Bian
  • Liang-Lin Qiu
  • Zhong Li
  • Qizhan Liu
  • Jianmin Li
  • Xinru Wang
  • Shou-Lin Wang
Toxicology (2012) 300 (3): 138.
Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice
  • Xin Zhou
  • Jaime D'Agostino
  • Fang Xie
  • Xinxin Ding
Journal of Pharmacology and Experimental Therapeutics (2012) 341 (1): 233.
Nicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes
  • Natasha M. DeVore
  • Emily E. Scott
Journal of Biological Chemistry (2012) 287 (32): 26576.
Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice
  • Yang Lin
  • Yunyi Yao
  • Senyan Liu
  • Lihua Wang
  • Bhagavatula Moorthy
  • Dongsheng Xiong
  • Tao Cheng
  • Xinxin Ding
  • Jun Gu
Toxicology Letters (2012) 212 (2): 97.
Generation and Characterization of aCYP2A13/2B6/2F1-Transgenic Mouse Model
  • Yuan Wei
  • Hong Wu
  • Lei Li
  • Zhihua Liu
  • Xin Zhou
  • Qing-Yu Zhang
  • Yan Weng
  • Jaime D'Agostino
  • Guoyu Ling
  • Xiuling Zhang
  • Kerri Kluetzman
  • Yunyi Yao
  • Xinxin Ding
Drug Metabolism and Disposition (2012) 40 (6): 1144.
Formation and Repair of Pyridyloxobutyl DNA Adducts and Their Relationship to Tumor Yield in A/J Mice
  • Anna M. Urban
  • Pramod Upadhyaya
  • Qing Cao
  • Lisa A. Peterson
Chemical Research in Toxicology (2012) 25 (10): 2167.
Lung carcinogenesis by tobacco smoke
  • Stephen S. Hecht
International Journal of Cancer (2012) 131 (12): 2724.
The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis
  • Yang Luan
  • Guozhen Xing
  • Xinming Qi
  • Mengjun Wu
  • Chenggang Li
  • Jun Yao
  • Likun Gong
  • Takehiko Nohmi
  • Jun Gu
  • Wanhong Zhou
  • Saijing Zheng
  • Jin Ren
Archives of Toxicology (2012) 86 (11): 1753.
NNK-Induced Lung Tumors: A Review of Animal Model
  • Hua-Chuan Zheng
  • Yasuo Takano
Journal of Oncology (2011) 2011: 1.
Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models
  • Xi-Ling Jiang
  • Frank J. Gonzalez
  • Ai-Ming Yu
Drug Metabolism Reviews (2011) 43 (1): 27.
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation—A mammalian cell-based mutagenesis approach
  • Huai-chih Chiang
  • Chin-Ying Wang
  • Hui-Ling Lee
  • Tsui-Chun Tsou
Toxicology and Applied Pharmacology (2011) 253 (2): 145.
Chronic Nicotine Consumption Does Not Influence 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone–Induced Lung Tumorigenesis
  • Sharon E. Murphy
  • Linda B. von Weymarn
  • Melissa M. Schutten
  • Fekadu Kassie
  • Jaime F. Modiano
Cancer Prevention Research (2011) 4 (11): 1752.
Cytochrome P450–Mediated Pulmonary Metabolism of Carcinogens
  • Sisko Anttila
  • Hannu Raunio
  • Jukka Hakkola
American Journal of Respiratory Cell and Molecular Biology (2011) 44 (5): 583.
The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5
  • Fang Xie
  • Xin Zhou
  • Mary Beth Genter
  • Melissa Behr
  • Jun Gu
  • Xinxin Ding
Drug Metabolism and Disposition (2011) 39 (6): 947.
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice
  • M.Christine Hollander
  • Xin Zhou
  • Colleen R. Maier
  • Andrew D. Patterson
  • Xinxin Ding
  • Phillip A. Dennis
Carcinogenesis (2011) 32 (8): 1279.
  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

AACR Journals

 

 

  • Copyright © 2022 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept