Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Role of the p38 Mitogen-Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide–Dependent Cellular Responses

Cancer Res (2006) 66 (13): 6763–6771.
This article has been cited by the following articles in journals that are participating in CrossRef Cited-by Linking.
Disease-associated metabolic pathways affected by heavy metals and metalloid
  • Zinia Haidar
  • Kaniz Fatema
  • Sabrina Samad Shoily
  • Abu Ashfaqur Sajib
Toxicology Reports (2023) 10: 554.
Oral arsenic administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR
  • Xiaojing Yang
  • André A. Weber
  • Elvira Mennillo
  • Miles Paszek
  • Samantha Wong
  • Sabrina Le
  • Jia Ying Ashley Teo
  • Max Chang
  • Christopher W. Benner
  • Robert H. Tukey
  • Shujuan Chen
Journal of Biological Chemistry (2023) 299 (3): 102955.
Intestinal homeostasis disruption in mice chronically exposed to arsenite-contaminated drinking water
  • A. Domene
  • H. Orozco
  • P. Rodríguez-Viso
  • V. Monedero
  • M. Zúñiga
  • D. Vélez
  • V. Devesa
Chemico-Biological Interactions (2023) 373: 110404.
Arsenic in medicine: past, present and future
  • Ngozi P. Paul
  • Adriana E. Galván
  • Kunie Yoshinaga-Sakurai
  • Barry P. Rosen
  • Masafumi Yoshinaga
BioMetals (2023) 36 (2): 283.
TP53 inhibitor PFTα increases the sensitivity of arsenic trioxide in TP53 wildtype tumor cells
  • Haiwei Wang
  • Xinrui Wang
  • Liangpu Xu
  • Ji Zhang
FEBS Open Bio (2022) 12 (3): 616.
Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
  • Lesley Jia Wei Pua
  • Chun-Wai Mai
  • Felicia Fei-Lei Chung
  • Alan Soo-Beng Khoo
  • Chee-Onn Leong
  • Wei-Meng Lim
  • Ling-Wei Hii
International Journal of Molecular Sciences (2022) 23 (3): 1108.
Structural Modification of Aminophenylarsenoxides Generates Candidates for Leukemia Treatment via Thioredoxin Reductase Inhibition
  • Zi-Long Song
  • Junmin Zhang
  • Qianhe Xu
  • Danfeng Shi
  • Xiaojun Yao
  • Jianguo Fang
Journal of Medicinal Chemistry (2021) 64 (21): 16132.
Relationship between p38 signaling pathway and arsenic-induced apoptosis: a meta-analysis
  • Liping Wu
  • Xi Li
  • Shaofeng Wei
  • Ting Hu
  • Changyan Wu
  • Wen Jian
  • Peng Luo
Environmental Geochemistry and Health (2021) 43 (3): 1213.
Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation
  • Yoshira M. Ayala-Marin
  • Alice H. Grant
  • Georgialina Rodriguez
  • Robert A. Kirken
International Journal of Molecular Sciences (2021) 22 (22): 12210.
CDK4/6 and MAPK—Crosstalk as Opportunity for Cancer Treatment
  • Lisa Scheiblecker
  • Karoline Kollmann
  • Veronika Sexl
Pharmaceuticals (2020) 13 (12): 418.
Identification of Histone H3 and H4 Amino Acid Residues Important for the Regulation of Arsenite Stress Signaling in Saccharomyces cerevisiae
  • Pilendra Kumar Thakre
  • Upendarrao Golla
  • Ashis Biswas
  • Raghuvir Singh Tomar
Chemical Research in Toxicology (2020) 33 (3): 817.
Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells
  • Chia-Hui Huang
  • Yuan-Chin Lee
  • Jing-Ting Chiou
  • Yi-Jun Shi
  • Liang-Jun Wang
  • Long-Sen Chang
Toxicology and Applied Pharmacology (2020) 397: 115013.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells
  • Mohammed A. Mansour
  • Wafaa M. Ibrahim
  • Eman S. Shalaan
  • Afrah F. Salama
Journal of Biochemical and Molecular Toxicology (2019) 33 (8)
MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
  • Lorenzo Stramucci
  • Angelina Pranteda
  • Arianna Stravato
  • Carla Azzurra Amoreo
  • Annarita Pennetti
  • Maria Grazia Diodoro
  • Armando Bartolazzi
  • Michele Milella
  • Gianluca Bossi
Cell Death & Disease (2019) 10 (11)
Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury
  • Jiachun Xu
  • Suli Cheng
  • Zhaohua Jiao
  • Zhiheng Zhao
  • Zhimin Cai
  • Nan Su
  • Baohong Liu
  • Zhen Zhou
  • Yan Li
CNS & Neurological Disorders - Drug Targets (2019) 18 (3): 245.
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling
  • James A. Thomas
  • Nicola Baker
  • Sebastian Hutchinson
  • Caia Dominicus
  • Anna Trenaman
  • Lucy Glover
  • Sam Alsford
  • David Horn
  • Joachim Clos
PLOS Neglected Tropical Diseases (2018) 12 (11): e0006980.
Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3
  • Kozo Nagai
  • Lihong Hou
  • Li Li
  • Bao Nguyen
  • Tessa Seale
  • Courtney Shirley
  • Hayley Ma
  • Mark Levis
  • Gabriel Ghiaur
  • Amy Duffield
  • Donald Small
Oncotarget (2018) 9 (68): 32885.
Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation
  • Jonathan B. Bell
  • Frank Eckerdt
  • Harshil D. Dhruv
  • Darren Finlay
  • Sen Peng
  • Seungchan Kim
  • Barbara Kroczynska
  • Elspeth M. Beauchamp
  • Kristen Alley
  • Jessica Clymer
  • Stewart Goldman
  • Shi-Yuan Cheng
  • C. David James
  • Ichiro Nakano
  • Craig Horbinski
  • Andrew P. Mazar
  • Kristiina Vuori
  • Priya Kumthekar
  • Jeffrey Raizer
  • Michael E. Berens
  • Leonidas C. Platanias
Molecular Cancer Research (2018) 16 (1): 32.
JNK, p38, ERK, and SGK1 Inhibitors in Cancer
  • Jonas Cicenas
  • Egle Zalyte
  • Arnas Rimkus
  • Dalius Dapkus
  • Remigijus Noreika
  • Sigitas Urbonavicius
Cancers (2017) 10 (1): 1.
Zinc Oxide Nanoparticle Induces Microglial Death by NADPH-Oxidase-Independent Reactive Oxygen Species as well as Energy Depletion
  • Anuj Kumar Sharma
  • Vikas Singh
  • Ruchi Gera
  • Mahaveer Prasad Purohit
  • Debabrata Ghosh
Molecular Neurobiology (2017) 54 (8): 6273.
Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23
  • Caley B. Shukalek
  • Diane P. Swanlund
  • Rodney K. Rousseau
  • Kevin E. Weigl
  • Vanessa Marensi
  • Susan P. C. Cole
  • Elaine M. Leslie
Molecular Pharmacology (2016) 90 (2): 127.
Direct Binding of Arsenic Trioxide to AMPK and Generation of Inhibitory Effects on Acute Myeloid Leukemia Precursors
  • Elspeth M. Beauchamp
  • Ewa M. Kosciuczuk
  • Ruth Serrano
  • Dhaval Nanavati
  • Elden P. Swindell
  • Benoit Viollet
  • Thomas V. O'Halloran
  • Jessica K. Altman
  • Leonidas C. Platanias
Molecular Cancer Therapeutics (2015) 14 (1): 202.
The Stress Kinase p38α as a Target for Cancer Therapy
  • Ana Igea
  • Angel R. Nebreda
Cancer Research (2015) 75 (19): 3997.
Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling
  • Wen-Jing Lu
  • Mei-Sze Chua
  • Samuel K. So
Oncotarget (2015) 6 (39): 41722.
Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting
  • Jessica K. Altman
  • Amy Szilard
  • Dennis J. Goussetis
  • Antonella Sassano
  • Marco Colamonici
  • Elias Gounaris
  • Olga Frankfurt
  • Francis J. Giles
  • Elizabeth A. Eklund
  • Elspeth M. Beauchamp
  • Leonidas C. Platanias
Clinical Cancer Research (2014) 20 (9): 2400.
Involvement of oxidative stress associated with glutathione depletion and p38 mitogen-activated protein kinase activation in arsenic disulfide-induced differentiation in HL-60 cells
  • Xiao-Mei Hu
  • Bo Yuan
  • Sachiko Tanaka
  • Qingbing Zhou
  • Kenji Onda
  • Hiroo Toyoda
  • Toshihiko Hirano
Leukemia & Lymphoma (2014) 55 (2): 392.
Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors
  • Edward J Wu
  • Dennis J Goussetis
  • Elspeth Beauchamp
  • Ewa M Kosciuczuk
  • Jessica K Altman
  • Elizabeth A Eklund
  • Leonidas C Platanias
Cancer Biology & Therapy (2014) 15 (4): 473.
Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide
  • Meysam Yousefi
  • Seyed H. Ghaffari
  • Ali Zekri
  • Samad Ghanizadeh-Vesali
  • Elham Hosseini
  • Masoumeh Rostami
  • Saeed Hassani
  • Kamran Alimoghaddam
  • Ardeshir Ghavamzadeh
Neurochemistry International (2013) 63 (8): 809.
Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation
  • Shunsuke Nakamura
  • Satoshi Nagano
  • Hiroko Nagao
  • Yasuhiro Ishidou
  • Masahiro Yokouchi
  • Masahiko Abematsu
  • Takuya Yamamoto
  • Setsuro Komiya
  • Takao Setoguchi
  • Wei-Guo Zhu
PLoS ONE (2013) 8 (7): e69466.
Regulation of the kinase RSK1 by arsenic trioxide and generation of antileukemic responses
  • John P. Galvin
  • Jessica K. Altman
  • Amy Szilard
  • Dennis J. Goussetis
  • Eliza Vakana
  • Antonella Sassano
  • Leonidas C. Platanias
Cancer Biology & Therapy (2013) 14 (5): 411.
Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer
  • Cynthia Guilbert
  • Matthew G. Annis
  • Zhifeng Dong
  • Peter M. Siegel
  • Wilson H. Miller
  • Koren K. Mann
  • Todd W. Miller
PLoS ONE (2013) 8 (12): e85995.
New Role for Granulocyte Colony-Stimulating Factor-Induced Extracellular Signal-Regulated Kinase 1/2 in Histone Modification and Retinoic Acid Receptor α Recruitment to Gene Promoters: Relevance to Acute Promyelocytic Leukemia Cell Differentiation
  • B. Cassinat
  • F. Zassadowski
  • C. Ferry
  • L. Llopis
  • N. Bruck
  • E. Lainey
  • V. Duong
  • A. Cras
  • G. Despouy
  • O. Chourbagi
  • G. Beinse
  • P. Fenaux
  • C. Rochette Egly
  • C. Chomienne
Molecular and Cellular Biology (2011) 31 (7): 1409.
Protein Kinase R as Mediator of the Effects of Interferon (IFN) γ and Tumor Necrosis Factor (TNF) α on Normal and Dysplastic Hematopoiesis
  • Bhumika Sharma
  • Jessica K. Altman
  • Dennis J. Goussetis
  • Amit K. Verma
  • Leonidas C. Platanias
Journal of Biological Chemistry (2011) 286 (31): 27506.
Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus
  • Chaitali Banerjee
  • Ramansu Goswami
  • Soma Datta
  • R. Rajagopal
  • Shibnath Mazumder
Toxicology and Applied Pharmacology (2011) 256 (1): 44.
Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species Level, Mitochondrial Dysfunction, Caspase Activation, and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide
  • Liu Liu
  • Chen Chen
  • Wei Gong
  • Yuanjing Li
  • Matthew L. Edin
  • Darryl C. Zeldin
  • Dao Wen Wang
Journal of Pharmacology and Experimental Therapeutics (2011) 339 (2): 451.
Regulatory Effects of Ribosomal S6 Kinase 1 (RSK1) in IFNλ Signaling
  • Barbara Kroczynska
  • Sonali Joshi
  • Elizabeth A. Eklund
  • Amit Verma
  • Sergei V. Kotenko
  • Eleanor N. Fish
  • Leonidas C. Platanias
Journal of Biological Chemistry (2011) 286 (2): 1147.
Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia
  • Dennis J. Goussetis
  • Leonidas C. Platanias
Clinical Cancer Research (2010) 16 (17): 4311.
AMPK as a therapeutic target in renal cell carcinoma
  • Jennifer Woodard
  • Sonali Joshi
  • Benoit Viollet
  • Nissim Hay
  • Leonidas C. Platanias
Cancer Biology & Therapy (2010) 10 (11): 1168.
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
  • Jennifer Woodard
  • Leonidas C. Platanias
Biochemical and Biophysical Research Communications (2010) 398 (1): 135.
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML
  • Rajesh R. Nair
  • Joel Tolentino
  • Lori A. Hazlehurst
Biochemical Pharmacology (2010) 80 (5): 602.
Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition
  • Jianguo Wen
  • Yongdong Feng
  • Wanting Huang
  • Haiyun Chen
  • Bing Liao
  • Lawrence Rice
  • Hector A. Preti
  • Rammurti T. Kamble
  • Youli Zu
  • Douglas J. Ballon
  • Chung-Che Chang
Leukemia Research (2010) 34 (1): 85.
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
  • Jynho Kim
  • John J. Lee
  • James Kim
  • Dale Gardner
  • Philip A. Beachy
Proceedings of the National Academy of Sciences (2010) 107 (30): 13432.
Role of Interferon α (IFNα)-inducible Schlafen-5 in Regulation of Anchorage-independent Growth and Invasion of Malignant Melanoma Cells
  • Efstratios Katsoulidis
  • Evangelos Mavrommatis
  • Jennifer Woodard
  • Mario A. Shields
  • Antonella Sassano
  • Nathalie Carayol
  • Konrad T. Sawicki
  • Hidayatullah G. Munshi
  • Leonidas C. Platanias
Journal of Biological Chemistry (2010) 285 (51): 40333.
Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide
  • Dennis J. Goussetis
  • Jessica K. Altman
  • Heather Glaser
  • Jennifer L. McNeer
  • Martin S. Tallman
  • Leonidas C. Platanias
Journal of Biological Chemistry (2010) 285 (39): 29989.
Arsenic Trioxide-Dependent Activation of Thousand-and-One Amino Acid Kinase 2 and Transforming Growth Factor-β-Activated Kinase 1
  • Jennifer L. McNeer
  • Dennis J. Goussetis
  • Antonella Sassano
  • Blazej Dolniak
  • Barbara Kroczynska
  • Heather Glaser
  • Jessica K. Altman
  • Leonidas C. Platanias
Molecular Pharmacology (2010) 77 (5): 828.
Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses
  • Jessica K. Altman
  • Heather Glaser
  • Antonella Sassano
  • Sonali Joshi
  • Takeshi Ueda
  • Rie Watanabe-Fukunaga
  • Rikiro Fukunaga
  • Martin S. Tallman
  • Leonidas C. Platanias
Molecular Pharmacology (2010) 78 (4): 778.
p38 in chronic myelogenous leukemia: a target and a possible biomarker
  • Suman Kambhampati
Leukemia & Lymphoma (2009) 50 (12): 1909.
The anti‐leukaemic activity of novel synthetic naphthoquinones against acute myeloid leukaemia: induction of cell death via the triggering of multiple signalling pathways
  • Maher Hallak
  • Thida Win
  • Ofer Shpilberg
  • Shmuel Bittner
  • Yosef Granot
  • Itai Levy
  • Ilana Nathan
British Journal of Haematology (2009) 147 (4): 459.
Role of Schlafen 2 (SLFN2) in the Generation of Interferon α-induced Growth Inhibitory Responses
  • Efstratios Katsoulidis
  • Nathalie Carayol
  • Jennifer Woodard
  • Iwona Konieczna
  • Beata Majchrzak-Kita
  • Alison Jordan
  • Antonella Sassano
  • Elizabeth A. Eklund
  • Eleanor N. Fish
  • Leonidas C. Platanias
Journal of Biological Chemistry (2009) 284 (37): 25051.
Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois
  • Rodrigo Franco
  • Roberto Sánchez-Olea
  • Elsa M. Reyes-Reyes
  • Mihalis I. Panayiotidis
Mutation Research/Genetic Toxicology and Environmental Mutagenesis (2009) 674 (1-2): 3.
  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept