The synthesis of 0.01 millimole of diphenyl p-iodophenyl tetrazolium chloride from radioactive iodine (I131) is described. Following the intravenous injection of the radioactive tetrazolium salt into normal and tumor-bearing mice, radioactivity disappeared rapidly from the circulating blood, and appeared in greatest amount in kidney, liver, and lung. Sarcoma 37 contained less radioactivity than most other tissues.

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This investigation was aided by a research grant from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

Acknowledgment is due Mr. Myron Milden for technical assistance.

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