An adenocarcinoma of the uterus was found in an endocrine imbalance female rat which died at 816 days of age. The endocrine imbalance was produced by the presence of a testis graft received at birth, and consisted of a constant relationship between gonadotrophic hormone and the ovary such that estrogen was released at a constant level throughout the life of the rat. The tumor involved the entire left horn of the uterus and the ovary. It had invaded the peritoneum and had been carried through the lymphatics to the region of the lesser curvature of the stomach where it involved the pancreas, liver, spleen, serosa of the stomach and esophagus.
This investigation was aided by grants from The Anna Fuller Fund and the National Cancer Institute (U.S.P.H.S.).