Of 185 endocrine imbalance female rats, 16 survived over 3 years. Leiomyomas were present in 4 of these 16 animals. One animal had multiple tumors; 2 were located in the middle and lower third of the right cornu, and a third was near the cervical end of the left cornu. The other 3 animals had single tumors. In one of these the tumor was located in the right cornu. In the other 2 it was in the left cornu. It is believed that the chronic estrogen stimulation resulting from the endocrine imbalance increases the chance of smooth muscle tumor formation.

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This investigation has been supported by grants from The Anna Fuller Fund and the National Cancer Institute (U.S.P.H.S.).

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