1. An unusual condition of the interphase nucleus has been observed in tissues of man, rabbit, hamster, mouse and frog.

  2. In addition to the usual constituents, the nuclei contain acidophilic granules, fine refractile granules, a refractile element in the ground substance, and birefringent crystals.

  3. Cytochemical tests indicate that all four of these components contain protein. The crystals probably contain lipid as well.

  4. Nuclei of this type are found in all organs and in derivatives of all cell layers.

  5. The incidence of affected nuclei in the livers of mice shows a decrease in variability and in median values with age. It is not influenced by 24 hour fasting.

  6. The condition is considered with respect to certain pathological features that seem to be associated with higher numbers of affected nuclei and to certain virus diseases.

  7. The incidence in tumors is closely similar to that in adjacent normal tissues, and the nuclei appear in organs of animals that are not ordinarily susceptible to the production of tumors in that organ as well as in those that are.

  8. It is not possible to say what causes the nuclear condition, but its wide occurrence suggests a process of some functional significance.

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Aided by a grant from the Elsa U. Pardee Foundation.

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