CIViC (civicdb.org) is an open access, expertly moderated knowledgebase for crowdsourcing Clinical Interpretations of Variants in Cancer. Stakeholders globally-including those in government, academia, industry and medicine-use CIViC to find and curate actionable interpretations of genomic variants in their therapeutic, prognostic, predisposing, diagnostic and functional contexts. Through engagement with curators and leaders in the field, CIViC has implemented several features including Assertions, Organizations and expanded help documentation.
The foundational unit of CIViC is the Evidence Item, which describes the clinical relevance of a specific variant curated from a single published source within peer-reviewed literature or ASCO abstract. Assertions aggregate Evidence Items for a given variant-disease or variant-disease-therapy combination. In response to the 2017 AMP-ASCO-CAP guidelines and collaborations with ClinGen, Assertions were modified to integrate ACMG variant pathogenicity classifications, AMP-ASCO-CAP tier designations and associations with NCCN guidelines and FDA approvals to provide a ‘state of the field' interpretation. At present, 12 Assertions spanning eight variants have been submitted by CIViC to ClinVar with one-star submitter status (Submitter ID: 506594), and CIViC has been cited as supporting information in two variants. Assertions exemplify CIViC's responsiveness to new field guidelines, expert collaborators' recommendations and its contributions to other resources.
To enhance community involvement, CIViC created Organization-attributed actions. Each action performed by a curator is tagged with their Organization. Curators may switch between Organizations if they belong to more than one. Currently, nine Organizations are recognized in CIViC, the largest being ClinGen with 79 members, 4 sub-organizations and over 24,000 actions. Organizations enable groups to prominently display and track their submissions, activity, and users.
CIViC's wide adoption has necessitated the development of robust educational material. CIViC has created nine YouTube videos, one of which is linked by the NIH ITCR homepage. CIViC has migrated help documents to a stand alone site (civic.readthedocs.io) and has made over 60 page modifications since 2019. Help documentation expansion was fueled by user feedback via the CIViC interface, collaborator meetings and in-person events (Curation Jamborees). Improved documentation allows CIViC to grow at scale, unhindered by the need for direct training.
CIViC's rapid adaptation to the needs of the community is derived from its open access nature, commitment to data provenance, active connection with users, and abundance of educational material. CIViC rapidly integrates the guidelines, regulatory standards and community recommendations in a freely accessible resource that is flexible enough to evolve with the dynamic field of cancer genomics.
Citation Format: Lana M. Sheta, Arpad M. Danos, Jason Saliba, Kilannin Krysiak, Alex H. Wagner, Erica K. Barnell, Susanna Kiwala, Joshua F. McMichael, Adam Coffman, Shahil Pema, Lynzey Kujan, Kelsy C. Cotto, Cody Ramirez, Zachary L. Skidmore, Cameron J. Grisdale, Shruti Rao, Subha Madhaven, Malachi Griffith, Obi L. Griffith. CIViC knowledgebase adapts to field experts and community input [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 206.