Bone marrow metastases are frequently detected by unilateral bone marrow biopsy and aspiration (BMBA), which is invasive. In this study, the value of functional magnetic resonance imaging (MRI) of pelvis was compared with BMBA and its clinical implication was evaluated. Cancer patients with bone metastasis and CT scan of pelvis showed no bone metastasis at the site of BMBA were included. BMBA was performed after MRI scan. Apparent Diffusion Coefficient (ADC), volume transfer constant (Ktrans), Pure diffusion coefficient (D), Pseudo diffusion coefficient (D*) and Perfusion fraction (f) were detected. The sensitivity, specificity and accuracy of MRI was calculate. An internal cross-validation via bootstrap was conducted for MRI performance in terms of the area under the curve (AUC). 28 oncological patients (11 breast cancer, 8 lung cancer, 5 prostatic cancer; 4 other cancers ) were enrolled. 16 patients were confirmed bone marrow metastases by BMBA. The sensitivity, specificity and accuracy of MRI was 93%, 50% and 75%. The ROC of Ktrans was 78%, which was the best. MRI can be used as a supplement to BMBA to diagnose bone marrow metastasis.
Citation Format: Hui Zhao, Zhiyu Wang, Yue Hua Li. Detection of bone marrow metastases: Comparison of functional magnetic resonance imaging with bone marrow biopsy and aspiration [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4257.