Chemo-resistance is one of the major factors limiting the therapeutic efficacy and prognosis of non-small cell lung cancer (NSCLC) patients, especially with patients who harbor epidermal growth factor receptor (EGFR)-activating mutations. Accumulating evidence suggests that aberrant expression of long noncoding RNAs (lncRNAs) is in part associated with carcinogenesis. Therefore, we tried to identify lncRNAs and their potential target genes in drug-resistant NSCLC. We evaluated lncRNAs with drug-resistant NSCLC using microarray data and in vitro assays. W found that lots of lncRNAs were differentially expressed between the drug-resistant NSCLC cells (HCC827-gef) and its parental (HCC827) cells. Among them, LINC00461 was found to be up-regulated lncRNAs, and highly correlated with the drug resistance. Taken together, the present study provides the expression profiles of chemo-resistant lncRNAs and identifies LINC00461 as a potential biomarker associated with EGFR-TKI resistance in non-small cell lung cancer cells.

This work was supported by a National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MEST) (NRF-2016M3A9B6903499).

Citation Format: Ji Yun Lee, Thi-Thu-Trang Luu, Duc-Hiep Bach, Ruoci Hu, Donghwa Kim, Sang Kook Lee. Role of long noncoding RNA LINC00461 in EGFR-TKIs resistant non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3584.