SOX2, a member of the SOX family of transcription factors, play an important role of differentiation and morphogenesis of the esophagus. We previously revealed that SOX2 is the target of gene amplification at 3q26 in esophageal squamous cell carcinoma (ESCC) (Cancer Genet Cytogenet. 2010), and that SOX2 promotes ESCC cell proliferation in vitro and in vivo through the activation of the AKT/mTORC1 signaling pathway (Cancer Sci. 2013). However, the mechanisms by which SOX2 promotes AKT/mTORC1 signaling remain unknown. It is known that PTEN is a negative regulator of AKT and the PTEN gene is a target of the miR-17-92 cluster. In the present study, we showed that SOX2 up-regulated the expression of miR-17-92 cluster and repressed PTEN expression using RNA interference (RNAi)-mediated knockdown of SOX2 and enforced expression of SOX2. In summary, SOX2 promotes cell proliferation of ESCC through the miR-17-92 cluster /PTEN/AKT/mTORC1 pathway.

Citation Format: Kei Terasaki. Sox2 promotes cell proliferation of esophageal squamous cell carcinoma through the miR-17-92 cluster ,PTEN,AKT,mTORC1 pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2533. doi:10.1158/1538-7445.AM2017-2533