Tumors often promote the expansion and recruitment of a variety of circulating immune cells. Among them, macrophages can accumulate in large numbers in the tumor stroma and participate actively in cancer growth; however, our understanding of the origins and dynamics of these cells remains not fully explored. By using various modalities, including in vivo imaging, we have started to define where, when and how macrophage precursors are produced and traffic to the tumor stroma. The findings suggest new cancer-induced mechanisms that foster tumor-promoting immunity and identify novel cellular and molecular targets for therapeutic intervention.

Citation Format: Mikael Pittet. Cancer-promoting immunity. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr IA04. doi:10.1158/1538-7445.CHTME14-IA04

©2015 American Association for Cancer Research.
2015