Previous studies have demonstrated that chromosomal instability (CIN) is a consistent feature of the majority of solid tumors. In this current study, we sought to examine the published CIN70 gene signature in a cohort of cervical cancer patients treated at the Princess Margaret (PM) Cancer Centre (n = 79) and an independent cohort of The Cancer Genome Atlas (TCGA) cervical cancer patients (n = 130). Patients with a high CIN70 score had a higher number of copy number alterations (Spearman's correlation coefficient (r) = 0.28, p<0.001), and a higher percentage of genome altered (r = 0.19, p = 0.016). According to Kaplan-Meier analysis, the CIN70 signature achieved borderline significance for para-aortic nodal or distant relapse, with a hazard ratio of 3.02 and Wald p-value of 0.05, but not significant for overall, disease-free survival, or local relapse. In summary, these findings demonstrate that chromosomal instability plays an important role in cervical cancer, and is significantly associated with patient outcome. For the first time, this CIN70 gene signature provided prognostic value for patients with cervical cancer.

Citation Format: Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise Clarke, David Hedley, Richard Hill, Michael Milosevic, Anthony Fyles, Kenneth W. Yip, Fei-Fei Liu. Chromosomal instability as a prognostic marker in cervical cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5297. doi:10.1158/1538-7445.AM2015-5297