Chromate (VI) compounds are human carcinogen. Exposure by inhalation or ingestion causes lung and intestinal cancers. Current therapy has side effects, necessitating the search for antidote from medicinal plant such as Moringa oleifera (M.oleifera). This study was undertaken to evaluate the effect of ethanol extract of M. oleifera on potassium dichromate (K2Cr2O7) induced clastogenicity and kidney damage. Leaves of M.oleifera were air dried, powdered, extracted with ethanol and phytochemical analysis carried out. Thirty male rats were grouped into 6 of 5 animals each. Negative and positive control rats had water and 12mg/kg K2Cr2O7 once per week respectively. Test rats were exposed to 3.5 and 7.0 body weight M.oleifera alone for 35 days and / or 12 mg/kg body wt K2Cr2O7 once a week before they were sacrificed. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in the bone marrow while creatinine and urea levels were assessed in the serum. Kidney superoxide dismutase (SOD), glutathione S-transferase (GST) and malondialdehyde (MDA) levels were also determined. K2Cr2O7 significantly (p <0.05) increased mPCEs and urea while creatinine was decreased when compared with control. MDA was also markedly increased, while SOD and GST were significantly reduced. Severe kidney damage was observed in the same sets of animals. However, M.oleifera mitigated the toxicity by reversing the markers towards that of control. M.oleifera is rich in flavonoids and phenolics which may account for the observed .protection. The results suggest that extract of M.oleifera has valuable potentials in the treatment/management of chromate (VI) toxicity
Note: This abstract was not presented at the meeting.
Citation Format: Kazeem A. Akinwum, Ayobami W. Adedoja, Osifeso O. Osifeso, Adenike M. Adegboyega, Deborah O. Aralamo, Olaitan O. David, Kazeem A. Akinwumi. Mitagation of potassium dichromate micronuclei induction and kidney damage by ethanol extract of Moringa oleifera in Swiss albino rats. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4577. doi:10.1158/1538-7445.AM2015-4577