Nanotechnology is becoming increasingly successful in advancing site-specific drug delivery to cancer tissues. The ability to deliver drugs more effectively to a region of interest translates into less harmful side effects and more beneficial therapeutic action. This technology is currently in use in treating a number of human cancers. Certain therapeutic limitations are encountered, such as short circulation life, poor drug permeability, and drug resistance. These limitations can be addressed with the use of nanoscale particles that allow for controlled release of the drug. This presentation will educate the audience about approaches to treating cancer using new technologies.

Objectives

The main objective of this strategy is to minimize the side effects associated with chemotherapy, while enhancing the overall efficacy of the treatment of breast cancer, and other cancers.

- Tackle drug limitations by combining nanotechnology and chemotherapeutic methods that have been shown to increase therapeutic efficacy

- Measure the effects of this combinatorial strategy using a mouse model bearing human breast tumors

- Assemble the drug into a nanoscale shell in order to form a polymeric nanoparticle capable of providing controlled drug release.

- Create leaky vasculature in the vicinity of tumor tissue without affecting normal tissue

Methods

1st Method: Synthesis of a nanoparticle which encapsulates two chemotherapeutic agents, Paclitaxel and Cisplatin. The nanoparticle formed is a lipid-polymer hybrid whose main components are as follows: a core encapsulating the two drugs; a biocompatible shell to promote drug retention inside the core; and a polymer stealth layer outside the lipid shell to enhance nanoparticle stability and systemic circulation lifetime.

2nd Method: The tumor will be starved by limiting vascular growth using the drug, Endostatin. In addition, the permeability of the vasculature surrounding the tumor will be made more permeable for drug uptake by using a permability enhancing agent, iRGD.

Note: This abstract was not presented at the meeting.

Citation Format: Oliver Molina, Eugena Yu, Sarah Abdulabbas, Steve Lopez. Enhanced permeability of nanoscale chemotherapeutic agents for the treatment of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5375. doi:10.1158/1538-7445.AM2014-5375