KLF4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that KLF4 plays an important role in cell proliferation and/or differentiation. Several studies implied that KLF4 is associated with both tumour suppression and oncogenesis, but the function of KLF4 in the oral carcinogenesis has not been investigated. To address this issue we have generated an animal model of experimental tongue cancerous lesions in C57BL/6J mouse by using carcinogen 4-nitroquinoline-1-oxide (4NQO) in drinking water .And we detected the KLF4 expression in mouse tongue precancerous and cancer lesions by immunohistochemistry. Normally KLF4 was strongly expressed in the nuclei of mice tongue epithelial cells. The staining of KLF4 was gradually decreased from normal epithelial to hyperplasia to dysplasia, and markedly decreased in the squamous cell carcinomas. The results indicated that KLF4 could served as a tumour-suppressor functions in the oral carcinogenesis.

Citation Format: Man Liu, Ying Su, Xinyan Zhang. The dynamic changes of KLF4 in the oral squamous cell carcinogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 477. doi:10.1158/1538-7445.AM2014-477