Tumor markers such as carcinoembryonic antigen (CEA) and CA 19-9 are both widely used in the follow up of patients with gastric cancer. However, there are no definitive predictive markers for postopetrative recurrence. It has been reported that preoperative neutrophil lymphocyte ratio (NLR) was associated with prognosis of patients with gastrointestinal cancer. The aim of this study was to examine the impact of postoperative NLR on prediction for postoperative recurrence of gastric cancer. We retrospective reviewed data from 133 patients underwent curative surgical resection for gastric cancer between 2006 and 2010. Patients treated with preoperative chemotherapy or multiple cancers were excluded. We found 52 recurrent diseases which mainly included 29 cases with peritoneal dissemination, 13 with distant lymph node metastasis and 7 with liver metastasis. In univariate analysis, histological diffuse type, mascroscopical type 4 cancer, regional lymph node metastasis, lymphatic invasion in primary tumor, tumor diameter, elevated CEA or CA19-9, and elevated NLR. By ultivariate analysis, we found that elevated CA19-9 and NLR were independent predictive markers. Increased NLR was associated with diffuse type, peritoneal ddissemination, elevated CEA and preoperative NLR but not the presence or absence of adjuvant chemotherapy. In conclusion, postoperative NLR might be one of the surrogate markers for recurrence after curative surgery for gastric cancer.
Citation Format: Hiroaki Tanaka, Kazuya Muguruma, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa. Postoperative neutrophil-lymphocyte ratio as a surrogate marker for recurrence of gastric cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3634. doi:10.1158/1538-7445.AM2014-3634