Natural products constitute an emerging class of compounds for carcinogenesis prevention in a variety of solid tumor malignancies. Resveratrol is a compound that has outstanding efficacy on cancer prevention in in vitro carcinogenesis models but rapid solubility and metabolism limits its efficacy in animal models when delivered in the diet. However, if regional or topical delivery could be achieved effects of first pass metabolism might be avoided. In the present study, we sought to use aerosol resveratrol to examine whether it could inhibit Benzpyrene inducd pulmonary adenoma formation in A/J mice. Eight groups of 24 mice were given Benzpyrene and aerosol resveratrol was started either one week or 8 weeks after the conclusion of the Benzpyrene. Aerosolized resveratrol (1.0, 0.3, and 0.1 mg/kg) was delivered 5x per week Monday through Friday for weeks 2- 15. At the conclusion of the experiment animals were sacrificed and adenomas counted. We found that the animals tolerated the aerosol resveratrol without toxicity and without weight differences between all groups. Animals formed between 9 and 12 adenomas, on average throughout all groups. There were no effects of aerosol resveratrol on either early stage or late stage carcinogenesis, nor were there any trends between the groups. We conclude that the high water solubility of resveratrol likely allowed for its rapid transit and metabolism through the bronchioles and lung parenchyma and that possibly chemical modifications of resveratrol that allow for its deposition in the lung fields in a way to increase its residence time would allow for better efficacy.
Citation Format: Donna Seabloom, Art Gailbraith, Jenny Antonides, Beverly Wuertz, Lee Wattenberg, Frank G. Ondrey. Lack of efficacy of aerosolized resveratrol on B[A]P induced pulmonary adenoma formation in A/J mice. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4865. doi:10.1158/1538-7445.AM2013-4865