Recently a growing corpus of studies has highlighted the important aspect of Mesenchymal Stem Cell (MSC) therapy: systemically administered MSCs home to sites of cancer. In this study, we focused on a homing mechanism of human MSCs into cancer. First, we examined if cultured medium from cancer cell lines could modulate migration of MSCs, the secretion level of HMGB1 from six different colon cancer cell lines affected the migration capacity of MSCs. In addition, recombinant HMGB1 could increase the migration capacity in dose dependent manner. Finally, we applied MSCs intracutaneously into mice bearing colon cancer using a cell line which secreted high level of HMGB1. The in vivo bioluminescence live-image showed that MSCs surrounded the tumors within 48hours after their injection, additionally the immunohistochemistry revealed the existence of MSCs in the tumors. These findings are critical in understanding the role of MSCs in solid cancer, further they might facilitate therapeutic application of MSCs in the treatment of cancer.

Citation Format: Go Hoshino, Hiroshi Yagi, Hirotoshi Hasegawa, Yoshiyuki Ishii, Takashi Endo, Koji Okabayashi, Akimasa Yasuda, Masaya Nakamura, Hideyuki Okano, Yumi Matsuzaki, Yuko Kitagawa. HMGB1 regulates homing capacity of human mesenchymal stromal cells into colon cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 216. doi:10.1158/1538-7445.AM2013-216

©2013 American Association for Cancer Research
2013