Small-molecular therapeutics targeting chromatin-modifying enzymes offer promise for future treatment of cancers, but the most suitable ways to use such agents is still largely unknown. This lecture will explore several avenues of research aimed at advancing chromatin-based therapeutics, including the identification of cancer genetic dependencies involving chromatin, the creation of new cancer dependencies by altering cell states through chromatin modifications, and the discovery of novel small molecules that alter chromatin states.
Citation Format: Stuart L. Schreiber. Linking genetic features of human cancers and histone-modifying enzymes for future cancer therapies. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr IA25.