Abstract: Introduction and Objective: Prostate Cancer (PC) mortality is higher in Puerto Rico (PR) versus either US Hispanics or Caucasians, despite lower incidence. Also, PR has the highest self- reported prevalence of diabetes mellitus type 2 (DM) among all states and territories. Data on the association between DM and PC is mixed, but a prior study by our group suggested it may affect PC differentially by White vs. Black race. This has not been studied in Hispanic men. Methods: We conducted a retrospective analysis of men treated with RP between 2000-2010 at the San Juan, PR VA Hospital. Data collection is ongoing with 99 men identified to date treated between 2000 and 2003. The association between DM and PSA recurrence was tested using a Cox proportional hazards model. Results: Of the 99 abstracted to date, 21 had DM (21%). There were no differences in pre-operative features between men with and without DM (all p>0.14). Similarly, pathological features were similar between men with and without DM at surgery (all p>0.13). On unadjusted analyses, DM was significantly associated with increased risk of PSA recurrence (HR 2.81, 95% CI 1.31-6.07, p=0.008). These results did not vary significantly after adjusting for age, BMI, Gleason score, and PSA (HR 2.61, 95% CI 1.16-5.89, p=0.021). Updated data will be presented. Conclusion: In a radical prostatectomy cohort of Hispanic men from PR, our preliminary data showed that men with DM at the time of surgery had significantly higher rates of PSA recurrence. As this is the first study of DM and RP outcomes in Hispanic men, these results require validation both in our full cohort and in other datasets. If confirmed, further research is needed to better understand why DM is linked with aggressive PC in Hispanics and whether this information can be used to identify better prevention and treatment strategies for PC, especially for Hispanic men.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 672. doi:1538-7445.AM2012-672

©2012 American Association for Cancer Research
2012