Background: Reduced quality of life, limited performance and fatigue are commonly observed side effects of breast cancer systemic treatment. In previous studies sport therapy could improve these symptoms. Sport has also been reported to positively impact the clinical course of the disease. So far it has remained unclear if these influences on clinical outcome are caused by alterations in the immune system or in tumor biology or in glucose or fat metabolism.

The aim of this study is to analyse the implications of individual interventions in exercise therapy on endurance, muscle strength, fatigue and quality of life, alterations in the immune system or in tumor biology or in glucose or fat metabolism for breast cancer patients during chemo therapy.

Method: The trial is prospectively randomised and controlled and will involve 60 breast cancer patients receiving adjuvant chemotherapy. 20 patients each are randomized into a strength training group, an endurance training group or a control group (with standard care). At the beginning and after 12 weeks the following tests are undertaken: isometric maximum strength test, a PWC 150 test to determine the endurance of patients. The standardised questionnaire EORTC QLQ C30 including module BR23 to measure quality of life and the questionnaire MFI-20 to determine symptoms of fatigue are filled in. Questionnair D2 measures ability to concentrate. Immunologic parameters as CD4, CD8 and T-REG-cells (FACS-Analysis), the number of the circulating tumour cells (measured by density gradient centrifugation) and also the concentration of glucose, insulin, leptin and adiponectin are being measured at study entry and after 12 weeks.

Momentarily patients are being screened, recruited and randomised into the trial. The final evaluation of the results is planned II/ 2013.

Discussion: The purpose of this study is to show if additional value can be added by individualized strength- or endurance training. Stabilisation or improvement of maximum strength and endurance during chemotherapy, as well as increase of quality of life and reduction of symptoms of fatigue would be a major improvement. Knowledge about effects of physical activity on circulating tumour cells as well as on immunologic alterations and on glucose and fat metabolism under chemotherapy could lead to a more specific counseling of patients and an individualized training program during chemotherapy.

Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT3-2-01.