Lung cancer is the leading cause of cancer death in the worldwide. Despite advances in early diagnostic methods and treatment modarities, lung cancer is often diagnosed at an advanced stage and has a poor prognosis. There is a need for the development of new biomarkers for early detection, defining cancer risk, prognosis, and therapy targets. The purpose of this study was to investigate the molecular background of lung carcinogenesis and to search useful biomarkers for clinical treatment including early detection and prognosis prediction of lung cancer by performing proteome analysis of human lung adenocarcinoma. Subjects were cases with primary lung adenocarcinoma on which surgical resection was performed. Tumor and adjacent non-tumor tissue sample were collected and proteome analysis was carried out. All through the examined cases, 52 proteins were found overexpressed and 13 proteins localized in extracellular space were detected and these proteins were thought as potential biomarkers associated with lung adenocarcinoma. We noticed one protein of them and performed immunohistochemical staining, 94% of cases were expressed. We assessed the statistical significance of the associations between expression level of this protein and clinicopathologic variables, it was showed that this protein had possibility to be a novel prognosis prediction biomarker of lung adenocarcinoma. This study enables the indentification of biomarker candidates for novel tumor markers and therapetic targets that will eventually lead to early detection, prevention and treatment of cancer.

Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5554.