Cisplatin is an effective anticancer agent that is widely used in the treatment of testicular, ovarian, bladder and lung cancers. However, the development of resistance to cisplatin is a major obstacle to treatment. To understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistant cells. However, these studies did not conclusively identify the basis of cellular resistance to cisplatin.

Recently some studies have shown that micro RNAs play an important role in cancer cell resistance to chemotherapeutic agents and cancer development.

In this study, micro RNA expression profiles of cisplatin resistant non small cell lung cancer cell lines were analyzed using microarray and real time RT-PCR. We found some of micro RNAs were similarly regulated in couple of cisplatin resistant cell lines. These finding are useful for understanding the miRNA mediated cisplatin resistance mechanisms. Now, functional analyses on miRNAs involving cisplatin resistance are in progress.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3542.