Results on the association between smoking and respiratory cancer arise from studies which have been primarly conducted among men, and few studies have examined in detail this relationship among women. As part of a large population based case-control study conducted in France between 2002 and 2007 (the ICARE study), 618 and 368 incident female cases with respectively lung and head and neck cancer were interviewed, as well as 713 female population controls. Cases were identified in ten areas covered by a cancer registry; controls were selected by random-digit dialing, with frequency matching for age and region. Cases are all patients suffering from a primary, malignant tumor of the buccal cavity , pharynx, sinonasal cavities, larynx, bronchi and lung (International Classification of Diseases, 10th Revision, codes C00-C14; C30-C34). Only histologically confirmed cases aged less than 75 at diagnosis will be included. All histological types were included. Subjects were interviewed face to face using a standardized questionnaire. In addition to socio-demographic characteristics, residential history, occupational history, medical history, family history, alcohol consumption, detailed information on smoking was collected: smoking of cigarettes, cigars, cigarillos and pipe, with beginning and end dates, quantity per day, type of cigarette (blond or brown tobacco, filtered or not, brand), for each smoking episode ; questions on snuff or chewing tobacco. We will present results on mean number of cigarettes smoked per day, total duration and pack-years. Information related to the type of tobacco smoked, age at starting and time since quitting will also be presented. Further, we have examined among controls the changing in smoking behavior according to birth cohort (quantity, age at starting, type of tobacco).

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2128.

100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO