Cisplatin is a chemotherapeutic agent for the treatment of many human cancers. However, it frequently induces side effects such as nephrotoxicity and hepatotoxicity. Thus, in present study, we investigated whether Bojungbangamtang (BJBAT) reduces cisplatin-induced toxicity. BJBAT was daily administered for 15 days to the BALB/c mice subcutaneously inoculated with CT-26 colon cancer cells. Even though BJBAT and cisplatin effectively suppressed tumor growth, combination therapy of BJBAT and cisplatin was more effective than treatment of BJBAT or cisplatin alone. BJBAT significantly attenuated the serum levels of aspartate ammoniumtransferase and alanine ammoniumtransferase, blood urea nitrogen and creatinine in the mice with nephrotoxicity and hepatotoxicity induced by cisplatin. Futhermore, BJBAT significantly increased antioxidant enzymse such as superoxide dismutase (SOD), catalase and glutatione peroxidase (GSH-Px) in liver and kidney of cisplatin treated mice. These data strongly suggest that BJBAT may reduce nephrotoxicity and hepatotoxicity induced by cisplatin via antioxidant activity.

99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA