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Background and aims: Metabolic syndrome has been associated with an increased risk of colon cancer, and this is a major health concern because of its death rates remain unacceptably high. Obesity and insulin resistance are important factor of metabolic syndrome. We found a positive association between visceral fat obesity and dysplastic aberrant crypt foci (ACF). Visceral fat is known for endocrine organ of adipocytokine such as adiponectin, leptin and IGF-1. Methods: ACF was examined in 42 cases with magnifying colonoscopy in Yokohama City University Hospital. All were personally interviewed to ascertain risk factors for colorectal cancer. We evaluated the association between age, BMI, waist, diabetes mellitus, serum lipid, visceral fat area, subcutaneous fat area, adipocytokine and dysplastic ACF. Results: Visceral fat area and adiponectin were significantly associated with dysplastic ACF. Conclusions: Adiponectin had an inverse correlation with dysplastic ACF, these results suggest that visceral fat obesity and adiponectin are important target for colon cancer prevention.

98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA