Discovery of somatic mutations in endometrial cancer Free

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The recent success of mutation-targeted therapy has lead to increased efforts for directed sequencing of protein tyrosine kinases (PTKs) to discover novel therapeutic targets of cancer. Here we report mutational analysis of exon-directed high-throughput sequencing of all PTKs across 42 endometrial tumor samples. The coding sequence analysis of 120 genes including 89 tyrosine kinases and 31 other genes implicated in cancer led to the identification of 100 validated somatic non-synonymous mutations across 36 genes. In concurrence with prior studies of endometrial cancer, our analysis identified known recurrent molecular lesions in TP53, PTEN, KRAS, CTNNB1 and PIK3CA. Novel somatic mutations will be presented, that provide considerable insights into the underlying complexity and heterogeneity of the endometrial cancer genome.