The Asian Dust Events (ADEs) are wind dust storms originated from the deserts of the Mongolia and northern China to Korea or the West coast of USA in spring time. Although the ADEs increased cardio-respiratory mortality, limited studies have been conducted to evaluate the morbidity or biomarkers levels related to the ADEs. Urinary 1-hydroxypyrene glucuronide (1-OHPG) and 8-hydroxy-deoxyguanosine (8-OHdG) before and after the ADEs were evaluated through this study . The study subjects consisting of 272 children aged of 8-13 years old were recruited from Changchun, China and Seoul, Inchon, Korea during the April ADEs in 2003 (217 Korean and 55 Chinese). Urine samples were collected from the subjects before and after the ADEs. Urinary 1-OHPG levels were measured by synchronous fluorescence spectroscopy after immuno-affinity purification using monoclonal antibody 8E11. Levels of urinary 8-OHdG were measured by ELISA. There was no significant difference in urinary 1-OHPG before and after the ADEs. Mean (± SE) after the ADEs was1.44 ± 0.12 ng/ml and that before the ADEs was 1.55 ± 0.14 ng/ml (n=272, paired t-test p=0.25). However, levels of urinary 8-OHdG after the ADEs (9.77 ± 1.21 ng/ml) were higher than those before the ADEs (7.36 ± 1.18 ng/ml) (p=0.05). There were also a significant correlation between levels of urinary 1-OHPG and 8-OHdG both after (r=0.48, p<0.01) and before the ADEs (r=0.54, p<0.01). Although the ADEs were very mild in 2003 compare to previous years, our findings suggest that urinary 8-OHdG levels increased after the ADE. However, these results should be repeated in the future large study.
[Proc Amer Assoc Cancer Res, Volume 47, 2006]