Background: Evidence suggests that B-cell and Hodgkin lymphomas are immune-mediated hematologic malignancies. Methods: We examined common genetic variants in inflammatory-mediated genes as predictors of B-cell and Hodgkin lymphomas by comparing 539 sex- and age-frequency matched hospital-based controls (56.3% males; median age, 63 years; range, 17-96) to cases with histologically confirmed B-cell lymphoid neoplasms (n=258) and Hodgkin lymphoma (n=56). Forty-one single nucleotide polymorphisms in 24 genes were determined by direct sequence analysis of nested PCR products using allele-specific primers for genomic DNA. Haplotypes were inferred from unphased genotype data for 14 genes (IL1B, IL4, IL5, IL6, IL8RB, IL10, IL13, IL16, LTA, TNF, VCAM1, LEPR, EPHX1 and CARD1) by use of a weighted substitution expectation-maximization algorithm adjusted for sex, age and laboratory to control for residual confounding. Results: Overall, 2-loci haplotypes of IL16 and EPHX1 were over-represented among cases with B-cell lymphoma compared to controls (OR=1.31 [1.00-1.72] and OR=1.43 [1.00-2.03], respectively). Additional haplotype frequency estimates by category of B-cell lymphoid histology will be presented. Finally, compared to controls, a haplotype of LTA, was over-represented among cases with HD (OR=1.86 [1.09-3.18]), whereas a haplotype of VCAM1 was under-represented (OR=0.46 [0.23-0.93]). Conclusion: These data suggest that genetic variations in inflammatory-mediated genes may influence risk of B-cell and Hodgkin lymphomas.
[Proc Amer Assoc Cancer Res, Volume 46, 2005]