Introduction: Laboratories around the world conduct cancer research and their results fill thousands of journal pages each year. For investigators developing mouse models or using mouse strain resources, an important first step in designing their experiments is to survey cancer profiles of existing strains. The Mouse Tumor Biology Database (MTB) is designed to facilitate the selection and evaluation of mice as genetic models of human disease by providing data on incidence and latency of mouse tumors reported in the published literature and in colony surveys of strains maintained at The Jackson Laboratory. The database captures data on endogenously arising tumors (both spontaneous and chemically induced) in genetically defined mice (inbred, hybrid, mutant and genetically engineered mice). Data on tumors arising from transplantation or injected cell lines are not included. Database organization: Tumor data are manually curated, using controlled nomenclature and vocabularies where available to create records based on strain background and genetics, organs affected, tumor classification, tumor incidence and latency, somatic mutations, pathology, and other information key to understanding the tumor being described. For many records, users can access images of the tumor pathology to view histopathological features reported in a study. The information contained in the MTB database may help researchers determine what strain background and genetic loci are associated with a specific tumor type versus those that are associated with a spectrum of tumors and possibly serve a more general role in carcinogenesis. Integration with other databases: The MTB database is one of several mouse specific databases hosted at The Jackson Laboratory. In addition to the tumor data housed in MTB, MTB provides links to other related online resources, including the Mouse Genome Informatics database (MGI), the Mouse Phenome Database (MPD), the Biology of the Mammary Gland Web site, Festing’s Listing of Inbred Strains of Mice, the JAX® Mice web site, and the Mouse Models of Human Cancers Consortium’s (MMHCC’s) Mouse Repository. Access: The MTB database is updated regularly and is publicly accessible free of charge via the World Wide Web at http://www.tumor.informatics.jax.org. User support is available via e-mail to mgi-help@informatics.jax.org. MTB is supported by NCI grant CA89713.

[Proc Amer Assoc Cancer Res, Volume 46, 2005]