The expression level of the TSC22 gene in human cervical cancer was down-regulated. To investigate the gene’s functional role in cervical cancers, we constructed an adenovirus vector expressing TSC22 and used it to infect cervical cancer cell lines, HeLa, HT-3, Caski, SiHa. Overexpression of TSC22 inhibited E6 and E7 protein expression in HPV positive cells and activated TGF-β signaling pathways, markedly decreased cell growth, and a high rate of apoptosis. Thus, because loss of TSC22 expression may contribute to the development of a subset of cervical cancer cells, restoration of TSC22 expression may be a new strategy for cervical cancer treatment.
[Proc Amer Assoc Cancer Res, Volume 45, 2004]