A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix

Lee, Jung Young; Dong, Seung Myung; Kim, Hy Sook; Kim, Su Young; Na, Eun Young; Shin, Min Sun; Lee, Sug Hyung; Park, Won Sang; Kim, Kyoung Mee; Lee, Youn Soo; Jang, Ja June; Yoo, Nam Jin

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Articles| March 01 1998

A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix^¹

Jung Young Lee;

Jung Young Lee

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Seung Myung Dong;

Seung Myung Dong

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Hy Sook Kim;

Hy Sook Kim

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Su Young Kim;

Su Young Kim

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Eun Young Na;

Eun Young Na

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Min Sun Shin;

Min Sun Shin

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Sug Hyung Lee;

Sug Hyung Lee

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Won Sang Park;

Won Sang Park

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Kyoung Mee Kim;

Kyoung Mee Kim

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Youn Soo Lee;

Youn Soo Lee

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Ja June Jang;

Ja June Jang

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Nam Jin Yoo

Department of Pathology and Cancer Research Institute, Catholic University Medical College

,

Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]

;

Department of Pathology, Sungkyunkwan University, College of Medicine

,

Seoul 100-380 [H. S. K.]

; and

Department of Pathology, Seoul National University College of Medicine and Cancer Research Center

,

Seoul 110-799 [J. J. J.]

;

Korea

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Author & Article Information

²

To whom requests for reprints should be addressed, at the Department of Pathology, Catholic University Medical College, 505 Banpo-Dong, Socho-Gu, Seoul 137-701, Korea.

Received: December 02 1997

Accepted: January 28 1998

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1998

American Association for Cancer Research, Inc.

Cancer Res (1998) 58 (6): 1140–1143.

Abstract

Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2–13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.

¹

Supported in part by the Catholic Medical Center Research Fund for special projects and by the Korea Science and Engineering Foundation through the Cancer Research Center at Seoul National University.

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1998

American Association for Cancer Research, Inc.

A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix^¹

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A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix1

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A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix^¹