Ring chromosomes have been found with some regularity as solid tumors have come increasingly under cytogenetic study. The full genetic content and significance of these rings remain unclear. Dermatofibrosarcoma protuberans, a tumor of the deep dermis, consistently has supernumerary ring chromosomes, sometimes as the sole detectable cytogenetic change. Using a modified method for comparative genomic hybridization and fluorescent in situ hybridization with a panel of various probes, we found that these ring chromosomes consistently contain the chromosome 22 centromere along with interstitial sequences from chromosomes 17 and 22, specifically from regions 17q23–24 and 22q11–12. The ring chromosomes in dermatofibrosarcoma protuberans are vehicles for a particular pattern of relatively low-level genomic amplification of selected sequences.

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Supported by the Programme d'Actions Intégrées Franco-Italien GALILEE, the Centre National de la Recherche Scientifique, and grants from the Institut National de la Santé et de la Recherche Médicale-Caisse Régionale d'Assurance Maladie des Travailleurs Salariés (Marseille, France), Association pour la Recherche sur le Cancer (Villejuif), Fédération Nationale des Centres de Lutt contre le Cancer, France; the Italian National Research Council (special project Applicazioni Cliniche della Ricerca Oncologica), and the Italian Association of Cancer Research.

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©1995 American Association for Cancer Research.
1995
American Association for Cancer Research, Inc.