The drug-sensitive mutant UVS1, isolated from the Chinese hamster cell line CH09, was previously found to complement the UV sensitivity of the excision repair-defective rodent mutants representative of groups 1 to 8 (Hata et al., Cancer Res., 51:195–198, 1991; M. Numata et al., personal communication). Recently two new complementation groups of UV-sensitive CHO mutants, e.g., groups 9 and 10, have been identified (Stefanini et al., Cancer Res., 51: 3965–3971, 1991). In this paper we demonstrate that the repair defect in UVS1 cells is genetically different from those present in the mutants CH07PV and CH04PV, representing groups 9 and 10, respectively. Therefore, UVS1 represents a new complementation group of UV-sensitive rodent cell lines, the eleventh group.

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Supported by grants from the National Research Council of Italy (CNR Target Project Ingegneria Genetica) and from the Commission of European Communities (Contract Bi7-034).

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©1992 American Association for Cancer Research.
1992
American Association for Cancer Research, Inc.