Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.

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This work was supported by the Italian Association for Cancer Research, Ministero della Sanità, Rome, and by the Italian National Research Council (Special Project: Applicazioni Cliniche della Ricerca Oncologica).

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