Screening for Germ Line TP53 Mutations in Breast Cancer Patients

Børresen, Anne-Lise; Andersen, Tone Ikdahl; Garber, Judy; Barbier-Piraux, Noële; Thorlacius, Steinunn; Eyfjörd, Jorunn; Ottestad, Lars; Smith-Sørensen, Birgitte; Hovig, Eivind; Malkin, David; Friend, Stephen H.

Article navigation

Articles| June 01 1992

Screening for Germ Line TP53 Mutations in Breast Cancer Patients^¹

Anne-Lise Børresen;

Anne-Lise Børresen

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Tone Ikdahl Andersen;

Tone Ikdahl Andersen

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Judy Garber;

Judy Garber

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Noële Barbier-Piraux;

Noële Barbier-Piraux

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Steinunn Thorlacius;

Steinunn Thorlacius

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Jorunn Eyfjörd;

Jorunn Eyfjörd

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Lars Ottestad;

Lars Ottestad

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Birgitte Smith-Sørensen;

Birgitte Smith-Sørensen

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Eivind Hovig;

Eivind Hovig

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

David Malkin;

David Malkin

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Stephen H. Friend

Department of Genetics, Institute for Cancer Research, [A-L. B., T. I. A., E. H., B. S-S.], and Department of Oncology [L. O.], The Norwegian Radium Hospital

,

Oslo

,

Norway

; the

Cancer Center, Massachusetts General Hospital, Harvard Medical School

,

Boston, 02114 [N. B. P., D. M., S. H. F.]

; the

Dana Farber Cancer Institute

,

Boston, Massachusetts 02115 [J. G.]

; the

Icelandic Cancer Society

,

Reykjavik, Iceland [S. T., J. E.]

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author & Article Information

²

To whom requests for reprints should be addressed, at Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello N-0310 Oslo 3, Norway.

Received: February 19 1992

Accepted: April 15 1992

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1992

American Association for Cancer Research, Inc.

Cancer Res (1992) 52 (11): 3234–3236.

Abstract

The constant denaturant gel electrophoresis technique was used to screen for TP53 germ line mutations in 237 women with breast carcinoma (167 unselected patients, 30 patients with at least one first-degree relative with breast cancer, and 40 women diagnosed with breast cancer before age 35). A germ line mutation at codon 181 was noted in one of the unselected patients and a codon 245 mutation in one of the early-onset patients. Both had a family history of breast cancer and other malignancies suggestive of Li-Fraumeni syndrome. The codon 245 mutation was also present in this patient's affected mother.

¹

This work was supported by grants from the Norwegian Cancer Society, the Norwegian Council for Science and Humanities, The Nordic Fund for Technology and Industrial Development, Thorsteds Legacy, Grethe Harbitz Legacy for Cancer Research, The Icelandic Cancer Society Science Fund, The Research Fund of the University of Iceland, and The Medical Research Council of Canada.

1992

American Association for Cancer Research, Inc.

62 Views

177 Web of Science

Screening for Germ Line TP53 Mutations in Breast Cancer Patients^¹

Abstract

Citing articles via

Email alerts

AACR Journals

Screening for Germ Line TP53 Mutations in Breast Cancer Patients1

Abstract

Citing articles via

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only

Screening for Germ Line TP53 Mutations in Breast Cancer Patients^¹