Polyclonal Lymphocytosis of T-Cells Associated with Human T-Cell Leukemia Virus I

Posnett, David N.; McGrath, Helen A.; Scott, Rachelle A.; Scott McNutt, N.; Folkl, Robert; Hickey, Thomas D.; Macera, M. J.; Szabo, Paul

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Articles| May 01 1988

Polyclonal Lymphocytosis of T-Cells Associated with Human T-Cell Leukemia Virus I^¹

David N. Posnett;

David N. Posnett

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Helen A. McGrath;

Helen A. McGrath

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Rachelle A. Scott;

Rachelle A. Scott

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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N. Scott McNutt;

N. Scott McNutt

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Robert Folkl;

Robert Folkl

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Thomas D. Hickey;

Thomas D. Hickey

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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M. J. Macera;

M. J. Macera

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Paul Szabo

Departments of Medicine [D. N. P., H. A. M., R. A. S., R. F., P. S.] and Pathology [N. S. M., T. D. H.], Cornell University Medical College

,

New York, New York 10021

, and

Division of Genetics, Long Island College Hospital, State University of New York Health Science Center

,

Brooklyn, New York 11203 [M. J. M.]

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Author & Article Information

²

Cornell Scholar in Biomedical Science. To whom correspondence should be addressed, at Department of Medicine, Cornell University Medical College, Rm. S811, 515E. 71st St., New York, NY 10021.

Received: July 07 1987

Revision Received: November 30 1987

Revision Received: January 26 1988

Accepted: February 08 1988

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1988

Cancer Research, Inc.

Cancer Res (1988) 48 (9): 2595.

Abstract

A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell antigen receptor rearrangements. Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis.

¹

This work was supported in part by USPHS Grants CA 40192, and CA 35473 and an Investigator Award to D. N. P. from the Cancer Research Institute.

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1988

Cancer Research, Inc.

Polyclonal Lymphocytosis of T-Cells Associated with Human T-Cell Leukemia Virus I^¹

Abstract

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Polyclonal Lymphocytosis of T-Cells Associated with Human T-Cell Leukemia Virus I1

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Polyclonal Lymphocytosis of T-Cells Associated with Human T-Cell Leukemia Virus I^¹