The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.

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Supported in part by the Medical Research Council of Canada (R. S. B.), National Cancer Institute Grant CA-13311 (H. D. S.), the Orthopedic Research and Education Fund (Y. F. R., M. C. G., H. J. M.), and the Physician's Services Incorporated Foundation.

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©1988 American Association for Cancer Research.
1988
Cancer Research, Inc.