Enhancement of Clonal Proliferation of Mouse Mast Cells by a Tumor-promoting Phorbol Ester

Saito, Hirohisa; Sanai, Yutaka; Nakamura, Hironori; Watanabe, Naohiro; Ito, Tadaatsu; Nagai, Yoshitaka

Article navigation

Articles| May 01 1984

Enhancement of Clonal Proliferation of Mouse Mast Cells by a Tumor-promoting Phorbol Ester^¹

Hirohisa Saito;

Hirohisa Saito

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Yutaka Sanai;

Yutaka Sanai

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Hironori Nakamura;

Hironori Nakamura

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Naohiro Watanabe;

Naohiro Watanabe

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Tadaatsu Ito;

Tadaatsu Ito

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Yoshitaka Nagai

Second Department of Biochemistry, Faculty of Medicine, University of Tokyo

,

Hongo, Bunkyo-ku, Tokyo 113 [H. S., Y. S., Y. N.]

;

Departments of Pediatrics [H. S., H. N.] and Parasitology [N. W.], The Jikei University School of Medicine

,

Minato-ku, Tokyo 105

; and

Department of Pediatrics, Teikyo University School of Medicine

,

Itabashi-ku, Tokyo 117 [T. I.]

,

Japan

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author & Article Information

²

To whom requests for reprints should be addressed, at Second Department of Biochemistry, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan.

Received: September 13 1983

Accepted: February 09 1984

Online ISSN: 1538-7445

Print ISSN: 0008-5472

1984

Cancer Research, Inc.

Cancer Res (1984) 44 (5): 2110–2114.

Abstract

Mast cell colonies grew in methylcellulose when mouse spleen cells were cultured for 14 days in the presence of medium conditioned by concanavalin A-stimulated spleen cells. Tumorpromoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-didecanoate, enhanced the concanavalin A-stimulated spleen cell-conditioned medium-induced colony growth of mast cell progenitors. The effect of TPA on this colony growth was blocked by the addition of two antipromoters of experimental skin carcinogenesis, i.e., retinoic acid and dexamethasone.

These results show that TPA has the ability to enhance the clonal proliferation of mouse mast cells and that this effect of TPA is closely related to tumor-promoting activity.

¹

This work was supported in part by Grants-in-Aid for Cancer Research and Science Research from the Ministry of Education, Science and Culture, Japan, and by the Toray Science and Technology Grants.

This content is only available via PDF.

1984

Cancer Research, Inc.

Enhancement of Clonal Proliferation of Mouse Mast Cells by a Tumor-promoting Phorbol Ester^¹

Abstract

Citing articles via

Email alerts

AACR Journals

Enhancement of Clonal Proliferation of Mouse Mast Cells by a Tumor-promoting Phorbol Ester1 Free

Abstract

Citing articles via

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only

Enhancement of Clonal Proliferation of Mouse Mast Cells by a Tumor-promoting Phorbol Ester^¹