Twenty-one cases of newly diagnosed nonlymphocytic leukemia were subjected to analysis of immunoglobulin gene organization. Although immunoglobulin gene organization is an essential property of B-lineage cells, immunoglobulin gene rearrangement has also been observed in mouse T-cells and occasionally in cultured human T-cell leukemic cells. Here we report the first case of acute myelogenous leukemia in which µ-chain gene rearrangement is demonstrated. This finding provides a further step in our understanding of both normal and abnormal hematopoietic cell differentiation and the heterogeneity of nonlymphocytic leukemia.


This work was supported by the Medical Research Council of Canada, the National Cancer Institute, and the Ontario Cancer Treatment and Research Foundation.

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