Inductions of monoclonal tumors, as judged by their single phenotype of phosphoglycerate kinase, in mice with X-chromosome inactivation mosaicism, were observed after s.c. injection of doses of 3-methylcholanthrene of 0.005 to 2 mg/mouse. The tumors induced (79% fibrosarcomas) exhibited the single-enzyme phenotype with 93% frequency at the lowest dose and with 57% frequency at the highest dose, indicating the dependence of monoclonal tumor induction on the dose of carcinogen.

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This work was supported by Grants-in-Aid for Cancer Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture of Japan and by a grant from the Adult Disease Clinic Memorial Foundation.

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