The human pancreatic cancer cell line COLO 357 has been xenografted s.c. in athymic Swiss mice. The xenografts grew well to form typical adenosquamous carcinomas. The cells were placed in a perfused artificial capillary system where they formed a solid tumor mass which survived for 7 weeks. In this system, the cells consumed glucose and released enzymes and carcinoembryonic antigen into the extracapillary space.
Supported by Grant CA 24485, from the National Pancreatic Cancer Project; Grants CA 30035, CA 13943, CA 20892, and CA 15018 from the National Cancer Institute, United States Department of Health and Human Services; and by a grant from the Veterans Administration.